IL13RA1 Antibody

Code CSB-PA003019
Size US$167Purchase it in Cusabio online store
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  • Western Blot analysis of COLO205 cells using IL-13Rα1 Polyclonal Antibody
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Product Details

Uniprot No. P78552
Target Names IL13RA1
Alternative Names IL13RA1; IL13R; IL13RA; Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19; CT19; CD antigen CD213a1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from Human IL-13Rα1 around the non-phosphorylation site of Y405.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Gene References into Functions
  1. High IL13RA1 expression is associated with Invasive breast Cancer. PMID: 28634667
  2. in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID: 28528324
  3. sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID: 28874358
  4. IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID: 26153764
  5. required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID: 25766112
  6. Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID: 25896327
  7. miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID: 25529447
  8. MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID: 23965966
  9. In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID: 23169588
  10. These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID: 21294892
  11. The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID: 21425907
  12. IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID: 21236478
  13. Mutation and functional analysis in human malignant glioma cells PMID: 11939409
  14. IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID: 12522691
  15. Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID: 12594065
  16. Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID: 14527737
  17. Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID: 16918506
  18. IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID: 17006604
  19. the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID: 17392323
  20. concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID: 19654941

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Subcellular Location Membrane; Single-pass type I membrane protein.
Protein Families Type I cytokine receptor family, Type 5 subfamily
Tissue Specificity Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
Database Links

HGNC: 5974

OMIM: 300119

KEGG: hsa:3597

STRING: 9606.ENSP00000360730

UniGene: Hs.496646

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