INTU Antibody, FITC conjugated

Datasheet
Code CSB-PA891544LC01HU
Size US$299
Uniprot No. Q9ULD6
Immunogen Recombinant Human Protein inturned protein (6-139AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6), INTU, KIAA1284 PDZD6 PDZK6
Immunogen Species Human
Protocols ELISA Protocol
Research Area Cell Biology
Target Names INTU
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies
Subcellular Location Cytoplasm, Cell surface, Cytoplasm, cytoskeleton, cilium basal body
Protein Families Inturned family
Database Links

HGNC: 29239

OMIM: 610621

KEGG: hsa:27152

STRING: 9606.ENSP00000334003

UniGene: Hs.391481

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