IZUMO1 Antibody

Datasheet

Code	CSB-PA812903LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA812903LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA812903LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) IZUMO1 Polyclonal antibody

Uniprot No.

Q8IYV9

Target Names

IZUMO1

Alternative Names

FLJ61440 antibody; IZUM1_HUMAN antibody; IZUMO antibody; Izumo sperm egg fusion 1 antibody; Izumo sperm-egg fusion protein 1 antibody; Izumo1 antibody; MGC34799 antibody; OBF antibody; Oocyte binding/fusion factor antibody; Sperm specific protein izumo antibody; Sperm-specific protein izumo antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Izumo sperm-egg fusion protein 1 protein (22-292AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The IZUMO1 Antibody (Product code: CSB-PA812903LA01HU) is Non-conjugated. For IZUMO1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA812903LB01HU	IZUMO1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA812903LC01HU	IZUMO1 Antibody, FITC conjugated
Biotin	CSB-PA812903LD01HU	IZUMO1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.

Gene References into Functions

crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction PMID: 27309808
crystal structures of human IZUMO1 and JUNO in unbound and bound conformations PMID: 27309818
these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein. PMID: 23279005
human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs [Izumo] PMID: 15759005
We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions. PMID: 18082733
Observational study of gene-disease association. (HuGE Navigator) PMID: 18082733

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein.

Protein Families

Izumo family

Tissue Specificity

Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.

Database Links

HGNC: 28539

OMIM: 609278

KEGG: hsa:284359

STRING: 9606.ENSP00000327786

UniGene: Hs.400688

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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