JAM3 Antibody, HRP conjugated

1. JAM-C plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress. PMID: 28203682
2. JAM-C controls Src family kinase (SFK) activation in leukemic stem cells and leukemia-initiating cell activity with exacerbated SFK activation was uniquely found within the JAM-C-expressing leukemic stem cell compartment. PMID: 28972073
3. The role of JAM-C in the engraftment of human lymphoma B cells in mice was investigated. The binding of anti-JAM-C antibodies inhibited the phosphorylation of ERK1/2, without affecting other signaling pathways, identifying for the first time the intracellular MAPK cascade as the JAM-C-driven signaling pathway in JAM-C(+) B cells. PMID: 27256571
4. blocking JAM-C can reduce the number of atherogenic monocytes/macrophages in plaques by emigration. PMID: 27442505
5. Palmitoylation of JAM-C promotes its localization to tight junctions and inhibits transwell migration of A549 lung cancer cells. PMID: 28196865
6. Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils. PMID: 26841848
7. Suggest JAM3-M4 methylation as a biomarker for diagnosis of preneoplastic and neoplastic lesions of the cervix. PMID: 26517242
8. JAM-C inactivation in endothelial cells resulted in increased spreading on fibronectin and enhanced sprouting in vitro in a manner dependent on beta1-integrin and on the activation of the small GTPase RAP1. PMID: 26311310
9. indicate that JAM-C may be a therapeutic target for preventing and treating lymphatic metastases PMID: 24584816
10. These findings provide evidence for a role for endothelial cell JAM-C in tumor growth and aggressiveness as well as recruitment of pericytes to newly formed blood vessels in a model of ovarian cancer. PMID: 23825230
11. Our study confirms the importance of JAM3 as a component of the junctional complexes and its deficiency leading to a distinctive and catastrophic neonatal presentation of cataracts and hemorrhagic destruction of the brain. PMID: 23255084
12. In the present study, we investigated the role of JAM-C in homing of human B cells, using a xenogeneic nonobese diabetic/severe combined immunodeficient mouse model. PMID: 23221386
13. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis PMID: 21593193
14. Our results suggest that JAM3 is essential for maintaining the integrity of the cerebrovascular endothelium as well as for normal lens development in humans PMID: 21109224
15. Soluble JAM-C mediates facets of angiogenesis in vitro and contributes the angiogenic potential of rheumatoid arthritis synovial fluid. PMID: 20592283
16. Letter: investigated platelet JAM-C following platelet activation by several agonists. PMID: 20135068
17. molecular cloning & role as VE-JAM/JAM 2 receptor PMID: 11823489
18. JAM3 is a strong candidate gene for hypoplastic left heart syndrome PMID: 11944976
19. Facilitates JAM2 interaction with alpha4beta1 PMID: 12070135
20. The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. PMID: 12208882
21. JAM-C(3) MAY play a role in desmosomal structure/function. PMID: 15194813
22. JAM-C participates in neutrophil transmigration and thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies PMID: 15485832
23. Junctional adhesion molecule-C participates in the later steps of the leukoendothelial adhesion and transmigration cascade in an acute pulmonary inflammation model using transgenic mouse tissue overexpressing JAM-C. PMID: 15879142
24. the homophilic interaction of JAM-C can mediate tumor cell-endothelial cell interactions and may have a role in tumor cell metastasis PMID: 16118203
25. JAM-C is up-regulated by oxLDL and may thereby contribute to increased inflammatory cell recruitment during atherosclerosis PMID: 16195363
26. JAM-C is an integral component of the dermal fibroblast adherens-like junction, and co-localizes with ZO-1. PMID: 16916751
27. Helps to regulate vascular permeability and pathologic angiogenesis through modulation of vascular endothelium (VE) contractility and VE-cadherin-mediated adhesion. PMID: 17116731
28. the expression of JAM-C promotes metastasis by enhancing both the adhesion of cancer cells to extracellular matrices and the subsequent invasion PMID: 17227766
29. expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C-lymphoproliferative syndromes and JAM-C+ ones PMID: 17429428
30. The results of these studies suggest a role for JAM-C in the pathogenesis of arthritis. PMID: 17612407
31. blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compartment through increased reverse transmigration rather than by reduced transmigration PMID: 17625065
32. Examine JAM-3 expression in normal/inflammed lymphatic endothelium. PMID: 17822725
33. study shows JAM-C was expressed in human sural nerves with an expression profile similar to that seen in mice PMID: 18048693
34. JAM-C *junctional adhesion molecule C) mediates recruiting and retaining leukocytes in the Rheumatoid arthritis synovium PMID: 18821692
35. JAM-C expression is variable in different epithelial cell lines with co-localization at tight junctions. PMID: 19143587
36. JAM-C gene expression is transcriptionally induced during activation of T lymphocytes via a calcineurin-dependent signaling pathway. PMID: 19204148
37. The regulation of EC junctional integrity involves the coordinated and dynamic modification of localization and activity of junctional stabilizers such as the integrin beta(3) and the destabilizer, JAM-C. PMID: 19461049
38. These studies suggest a function for coxsackievirus and adenovirus receptor (CAR) in male fertility. PMID: 16410001
39. Functions as a facilitator for JAM2/alpha4beta1 interactions PMID: 12070135
40. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. PMID: 11590146

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HGNC: 15532

OMIM: 606871

KEGG: hsa:83700

UniGene: Hs.150718