JARID2 Antibody, Biotin conjugated

1. rs2237126 in JARID2 is not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
2. The knockdown of JARID2 inhibited the viability and invasion of trophoblast cells in preeclampsia by suppressing the PI3K/Akt signaling pathway. PMID: 28714012
3. bservations suggested that knockdown of JARID2 inhibited proliferation, migration and invasion in vitro through the inactivation of the PI3K/Akt signaling pathway. Therefore, JARID2 may represent a potential therapeutic target for the treatment of ovarian cancer. PMID: 28765957
4. Authors found that knockdown of Jarid2 was able to inhibit the invasive ability and sphere-forming capacity in bladder cancer cells. PMID: 28445934
5. Our results suggest that JARID2 rs2237138 shows a protective effect against NSCL +/- P (non-syndromic oral clefts)in the Brazilian population. PMID: 27328068
6. JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling PMID: 27259236
7. JARID2 plays an important role in glioma development. PMID: 27641964
8. Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility. PMID: 25155265
9. JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression PMID: 25939703
10. TGF-ss-dependent expression changes of EMT-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression. PMID: 25542019
11. Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb repressive complex 2 (PRC2) activity depending on the chromatin context. PMID: 25620564
12. Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function PMID: 25645357
13. Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2. PMID: 24889693
14. miR-155 regulates the fate of Th17 and Treg cells and miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2. PMID: 24856900
15. The interaction of JARID2 at these promoters is dependent on EED. PMID: 23435416
16. Jarid2 is an important mediator of Xist-induced PRC2 targeting. PMID: 24462204
17. The presence of long noncoding RNAs stimulated JARID2-EZH2 interactions in vitro and JARID2-mediated recruitment of PRC2 to chromatin. PMID: 24374312
18. Patients carrying JARID2 deletion manifested with cognitive impairment, gait disturbance and a characteristic facial appearance, whereas patients with deletion of ATXN1 seemed to be characterized by intellectual disability and behavioural abnormalities PMID: 23294540
19. In chronic myeloproliferative neoplasms & myelodysplastic syndromes, there were frequent deletions in a 1.1 Mb region of the short arm of chromosome 6 containing only the JARID2 gene. This del6p was associated with leukemic transformation. PMID: 22190018
20. JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development PMID: 20075857
21. Two SNPs in JARID2 showed association in allelic, genotypic and haplotypic tests with schizophrenia patients from Chang Le area. PMID: 19884986
22. JMJ was evaluated against risk factors for spinal dysraphism and congenital heart defects. Variations within exons and introns of JMJ might be in linkage disequlibrium. PMID: 15057990
23. JARID2 should be viewed as a candidate gene for 6p22.3-linked schizophrenia PMID: 16967465
24. JARID2 appears important in transcriptional regulation of fetal genes and may emerge as a diagnostic marker for left ventricular decompensation in aortic stenosis. PMID: 18805276
25. Based on the findings the authors propose that miR-155 has a prosurvival function that is mediated through the downregulation of targets including JARID2. PMID: 19759154

Show More

Hide All

HGNC: 6196

OMIM: 601594

KEGG: hsa:3720

STRING: 9606.ENSP00000341280

UniGene: Hs.269059