JARID2

JARID2, also known as JMJ and DIDDF, is a DNA-binding protein that functions as a transcriptional repressor. It interacts with the Polycomb repression complex 2 (PRC2), which plays a crucial role in regulating gene expression during embryonic development. This protein helps recruit the PRC2 complex to target genes. JARID2 is involved in various physiological processes, including the cells response to leukemia inhibitory factor, hematopoietic or lymphoid organ development, and the regulation of gene expression. Mutations in JARID2 are associated with multiple diseases, such as chronic myeloid malignancies, nonspecific syndromes with intellectual disabilities, tetralogy of Fallot, Weaver syndrome, Kabuki syndrome 1, and autism spectrum disorders.