Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) JARID2 Polyclonal antibody

Uniprot No.

Q92833

Target Names

JARID2

Alternative Names

JARD2 antibody; JARD2_HUMAN antibody; JARID2 antibody; JMJ antibody; Jumonji AT rich interactive domain 2 antibody; Jumonji homolog antibody; Jumonji like protein antibody; Jumonji protein antibody; Jumonji/ARID domain containing protein 2 antibody; Jumonji/ARID domain-containing protein 2 antibody; Protein Jumonji antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein Jumonji protein (1-159AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.

Gene References into Functions

rs2237126 in JARID2 is not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
The knockdown of JARID2 inhibited the viability and invasion of trophoblast cells in preeclampsia by suppressing the PI3K/Akt signaling pathway. PMID: 28714012
bservations suggested that knockdown of JARID2 inhibited proliferation, migration and invasion in vitro through the inactivation of the PI3K/Akt signaling pathway. Therefore, JARID2 may represent a potential therapeutic target for the treatment of ovarian cancer. PMID: 28765957
Authors found that knockdown of Jarid2 was able to inhibit the invasive ability and sphere-forming capacity in bladder cancer cells. PMID: 28445934
Our results suggest that JARID2 rs2237138 shows a protective effect against NSCL +/- P (non-syndromic oral clefts)in the Brazilian population. PMID: 27328068
JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling PMID: 27259236
JARID2 plays an important role in glioma development. PMID: 27641964
Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility. PMID: 25155265
JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression PMID: 25939703
TGF-ss-dependent expression changes of EMT-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression. PMID: 25542019
Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb repressive complex 2 (PRC2) activity depending on the chromatin context. PMID: 25620564
Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function PMID: 25645357
Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2. PMID: 24889693
miR-155 regulates the fate of Th17 and Treg cells and miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2. PMID: 24856900
The interaction of JARID2 at these promoters is dependent on EED. PMID: 23435416
Jarid2 is an important mediator of Xist-induced PRC2 targeting. PMID: 24462204
The presence of long noncoding RNAs stimulated JARID2-EZH2 interactions in vitro and JARID2-mediated recruitment of PRC2 to chromatin. PMID: 24374312
Patients carrying JARID2 deletion manifested with cognitive impairment, gait disturbance and a characteristic facial appearance, whereas patients with deletion of ATXN1 seemed to be characterized by intellectual disability and behavioural abnormalities PMID: 23294540
In chronic myeloproliferative neoplasms & myelodysplastic syndromes, there were frequent deletions in a 1.1 Mb region of the short arm of chromosome 6 containing only the JARID2 gene. This del6p was associated with leukemic transformation. PMID: 22190018
JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development PMID: 20075857
Two SNPs in JARID2 showed association in allelic, genotypic and haplotypic tests with schizophrenia patients from Chang Le area. PMID: 19884986
JMJ was evaluated against risk factors for spinal dysraphism and congenital heart defects. Variations within exons and introns of JMJ might be in linkage disequlibrium. PMID: 15057990
JARID2 should be viewed as a candidate gene for 6p22.3-linked schizophrenia PMID: 16967465
JARID2 appears important in transcriptional regulation of fetal genes and may emerge as a diagnostic marker for left ventricular decompensation in aortic stenosis. PMID: 18805276
Based on the findings the authors propose that miR-155 has a prosurvival function that is mediated through the downregulation of targets including JARID2. PMID: 19759154