JPH1 Antibody

Datasheet
Code CSB-PA872553LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q9HDC5
Image
  • IHC image of CSB-PA872553LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system.

  • Immunofluorescence staining of Hela cells with CSB-PA872553LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Junctophilin-1 protein (431-546AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200
Relevance Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Junctophilin-1 (JP-1) (Junctophilin type 1), JPH1, JP1
Immunogen Species Human
Research Area Cell Biology
Target Names JPH1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Subcellular Location Cell membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Single-pass type IV membrane protein, Sarcoplasmic reticulum membrane, Single-pass type IV membrane protein
Protein Families Junctophilin family
Tissue Specificity Abundantly expressed in skeletal muscle. Very low levels in heart.
Database Links

HGNC: 14201

OMIM: 605266

KEGG: hsa:56704

STRING: 9606.ENSP00000344488

UniGene: Hs.657367

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