JPH1 Antibody

Datasheet

Code	CSB-PA872553LA01HU
Size	US$166
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Image	IHC image of CSB-PA872553LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. Immunofluorescence staining of Hela cells with CSB-PA872553LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) JPH1 Polyclonal antibody

Uniprot No.

Q9HDC5

Target Names

JPH1

Alternative Names

DKFZp762L0313 antibody; JP 1 antibody; JP-1 antibody; JP1 antibody; JPH 1 antibody; JPH1 antibody; JPH1_HUMAN antibody; Junctophilin 1 antibody; Junctophilin type 1 antibody; Junctophilin type1 antibody; Junctophilin-1 antibody; Junctophilin1 antibody; Mitsugumin 72 antibody; Mitsugumin72 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Junctophilin-1 protein (431-546AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The JPH1 Antibody (Product code: CSB-PA872553LA01HU) is Non-conjugated. For JPH1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA872553LB01HU	JPH1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA872553LC01HU	JPH1 Antibody, FITC conjugated
Biotin	CSB-PA872553LD01HU	JPH1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.

Gene References into Functions

This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden. PMID: 24954085
This study demonstrates that both JP1 and JP2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period PMID: 23148318
JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery PMID: 22020936

Subcellular Location

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein.

Protein Families

Junctophilin family

Tissue Specificity

Abundantly expressed in skeletal muscle. Very low levels in heart.

Database Links

HGNC: 14201

OMIM: 605266

KEGG: hsa:56704

STRING: 9606.ENSP00000344488

UniGene: Hs.657367

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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