KCNMB3 Antibody

Datasheet

Code	CSB-PA878838LA01HU
Size	US$166
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Image	Immunofluorescence staining of U251 cells with CSB-PA878838LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KCNMB3 Polyclonal antibody

Uniprot No.

Q9NPA1

Target Names

KCNMB3

Alternative Names

BK channel subunit beta 3 antibody; BK channel subunit beta-3 antibody; BKbeta 3 antibody; BKbeta3 antibody; Calcium activated potassium channel beta 3 subunit antibody; Calcium activated potassium channel subfamily M subunit beta 3 antibody; Calcium activated potassium channel subunit beta 3 antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta-3 antibody; Charybdotoxin receptor subunit beta 3 antibody; Charybdotoxin receptor subunit beta-3 antibody; EG435726 antibody; Gm5707 antibody; Hbeta 3 antibody; Hbeta3 antibody; K(VCA)beta 3 antibody; K(VCA)beta-3 antibody; KCMB3_HUMAN antibody; KCNMB 2 antibody; KCNMB 3 antibody; KCNMB2 antibody; KCNMB3 antibody; KCNMBL antibody; Large conductance voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit antibody; Maxi K channel subunit beta 3 antibody; Maxi K channel subunit beta-3 antibody; Potassium channel, calcium-activated large conductance, subfamily M, beta member 3 antibody; Potassium large conductance calcium activated channel beta 3 subunit antibody; Potassium large conductance calcium activated channel subfamily M beta member 3 antibody; Slo beta 3 antibody; Slo-beta-3 antibody; subfamily M subunit beta-3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Calcium-activated potassium channel subunit beta-3 protein (82-207AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KCNMB3 Antibody (Product code: CSB-PA878838LA01HU) is Non-conjugated. For KCNMB3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA878838LB01HU	KCNMB3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA878838LC01HU	KCNMB3 Antibody, FITC conjugated
Biotin	CSB-PA878838LD01HU	KCNMB3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Antigen Affinity purified & Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Gene References into Functions

Single-nucleotide polymorphism in KCNMB3 gene is associated with Insulin Resistance. PMID: 23826284
The frequency of the delA750 mutation was significantly increased in idiopathic generalized epilepsy (7.9%) compared to that in the controls (5.5%; P = 0.016, one-sided; OR = 1.52; 95%-CI: 1.05-2.21). PMID: 16958040
The KCNMB3 isoforms beta3a-d may have unique functions in primates. PMID: 18591419

Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

KCNMB (TC 8.A.14.1) family, KCNMB3 subfamily

Tissue Specificity

Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.

Database Links

HGNC: 6287

OMIM: 605222

KEGG: hsa:27094

STRING: 9606.ENSP00000319370

UniGene: Hs.591285

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Vascular smooth muscle contraction cGMP-PKG signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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