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Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
Gene References into Functions
High KIF4A expression is associated with lung cancer. PMID: 28160558
decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms. PMID: 28821562
Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable PMID: 27633014
Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review) PMID: 27196062
Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A. PMID: 25998931
KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase. PMID: 25512391
KIF4A might be a key regulator for tumoral progression in OSCCs. PMID: 24386490
Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function. PMID: 24812067
The KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1. PMID: 23940115
Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length. PMID: 23870126
KIF4 regulates midzone length during cytokinesis. PMID: 21565503
Loss of KIF4 expression is associated with gastric carcinoma. PMID: 20711700
Results demonstrating association of KIF4 with BRAF35 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals. PMID: 12809554
These results suggest that KIF4 is involved in cytokinesis, although direct evidence was not provided in this study. PMID: 15031677
KIF4 and its binding partner protein regulator of cytokinesis 1 play essential roles in the organization of central spindles and midzone formation PMID: 15297875
Human KIF4A is an essential chromosome-associated molecular motor involved in faithful chromosome segregation. HKIF4A localizes in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. PMID: 15326200
role of PRC1 in midzone formation, indicate that cell cycle-dependent translocation of PRC1 by Kif4 is essential for midzone formation and cytokinesis. PMID: 15625105
Zip1 and CR motifs are important for Kif4A chromatin-binding and its mitotic function. PMID: 18502200
results suggest a novel role for a chromokinesin family member Kif4 in the DNA damage response by modulating the BRCA2/Rad51 pathway PMID: 18604178
These studies identify a novel transit station through which Gag traffics en route to particle assembly and highlight the importance of KIF4 in regulating HIV-1 Gag trafficking and stability. PMID: 18684836
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Chromokinesin subfamily
Tissue Specificity
Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.