KIF4A Antibody

1. High KIF4A expression is associated with lung cancer. PMID: 28160558
2. decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms. PMID: 28821562
3. Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable PMID: 27633014
4. Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review) PMID: 27196062
5. Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A. PMID: 25998931
6. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase. PMID: 25512391
7. KIF4A might be a key regulator for tumoral progression in OSCCs. PMID: 24386490
8. Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function. PMID: 24812067
9. The KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1. PMID: 23940115
10. Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length. PMID: 23870126
11. KIF4 regulates midzone length during cytokinesis. PMID: 21565503
12. Loss of KIF4 expression is associated with gastric carcinoma. PMID: 20711700
13. Results demonstrating association of KIF4 with BRAF35 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals. PMID: 12809554
14. These results suggest that KIF4 is involved in cytokinesis, although direct evidence was not provided in this study. PMID: 15031677
15. KIF4 and its binding partner protein regulator of cytokinesis 1 play essential roles in the organization of central spindles and midzone formation PMID: 15297875
16. Human KIF4A is an essential chromosome-associated molecular motor involved in faithful chromosome segregation. HKIF4A localizes in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. PMID: 15326200
17. role of PRC1 in midzone formation, indicate that cell cycle-dependent translocation of PRC1 by Kif4 is essential for midzone formation and cytokinesis. PMID: 15625105
18. Zip1 and CR motifs are important for Kif4A chromatin-binding and its mitotic function. PMID: 18502200
19. results suggest a novel role for a chromokinesin family member Kif4 in the DNA damage response by modulating the BRCA2/Rad51 pathway PMID: 18604178
20. These studies identify a novel transit station through which Gag traffics en route to particle assembly and highlight the importance of KIF4 in regulating HIV-1 Gag trafficking and stability. PMID: 18684836

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HGNC: 13339

OMIM: 300521

KEGG: hsa:24137

STRING: 9606.ENSP00000363524

UniGene: Hs.648326