KLC1 Antibody

Datasheet
Code CSB-PA012379DSR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: KLC1 antibody at 1.34µg/ml
    Lane 1: Colo320 whole cell lysate
    Lane 2: HepG2 whole cell lysate
    Lane 3: SH-SY5Y whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 66, 64, 65, 72, 70, 67, 63, 73 kDa
    Observed band size: 72 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA012379DSR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA012379DSR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) KLC1 Polyclonal antibody
Uniprot No. Q07866
Target Names KLC1
Alternative Names Kinesin 2 60/70kDa antibody; Kinesin light chain 1 antibody; Kinesin2 antibody; KLC 1 antibody; KLC antibody; Klc1 antibody; KLC1_HUMAN antibody; KNS 2 antibody; KNS 2A antibody; KNS2 antibody; KNS2A antibody; Medulloblastoma antigen MU MB 2.50 antibody; MGC15245 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Kinesin light chain 1 protein (274-573AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Gene References into Functions
  1. structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding PMID: 29036226
  2. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients. PMID: 27891669
  3. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
  4. The G allele and GG genotype of KLC1 rs8702 were significantly over-represented among cataract patients, as compared to healthy controls, and were associated with an odds ratio for cataract development. PMID: 25883527
  5. Dnm1L interacts with KLC1 through the tetratricopeptide repeat domains. PMID: 25082190
  6. Microtubule-bound kinesin-1 and kinesin-3 motor domains were visualized at multiple steps in their ATPase cycles--including their nucleotide-free states--at approximately 7 A resolution using cryo-electron microscopy. PMID: 25209998
  7. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. PMID: 24116125
  8. The expression levels of KLC1 variant E in brain and lymphocytes were significantly higher in Alzheimer's disease patients. PMID: 24497505
  9. study provides evidence that the combined effect of three variants within the KLC1 gene may predispose to age-related cataract. PMID: 23776437
  10. For the binding of cargos shared by KLC1, we propose a different site located within the groove but not involving N343. PMID: 22470497
  11. Data suggest that KLC1 is required for normal neural differentiation, ensuring proper metabolism of AD-associated molecules APP and Tau and for proliferation of neural precursors (NPs). PMID: 22272245
  12. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1. PMID: 21385839
  13. Results do not convincingly support kinesin light chain 1 (KLC1) as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract. PMID: 19911314
  14. The major binding site for kinesin light chain in kinesin heavy chain has been mapped to residues 789-813 at the C-terminal end of the heavy chain stalk domain. PMID: 12475239
  15. For a single nucleotide polymorphism (G58836C in intron 13) in the kinesin light-chain 1 (KNS2) gene, the association between Alzheimer's disease and the C allele is found to be significant. PMID: 15364413
  16. KNS2 gene may play a role during early stages of Alzheimer's disease pathogenesis. PMID: 17611642
  17. KLC1 gene may be a novel susceptibility gene for age-related cataract. PMID: 17653041
  18. microtubule-dependent functions of von Hippel-Lindau tumour suppressor are influenced by kinesin-2 PMID: 17825299
  19. The present finding supports the involvement of the cytoskeleton and KNS2 in the development of vascular white matter damage, thereby opening up novel fields in the research into leukariois. PMID: 17977659
  20. The KLC1 56836CC variant exerts a significant protective effect on the occurrence of multiple sclerosis. PMID: 17999208
  21. The rs8702 variant of the kinesin light chain 1 genotype proved to exert strong amplifying effects on the occurrence and severity of leukoaraiosis in patients with long-lasting poorly controlled severe hypertension PMID: 19046961

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Subcellular Location Cell projection, growth cone, Cytoplasmic vesicle, Cytoplasm, cytoskeleton
Protein Families Kinesin light chain family
Tissue Specificity Found in a variety of tissues. Mostly abundant in brain and spine.
Database Links

HGNC: 6387

OMIM: 600025

KEGG: hsa:3831

STRING: 9606.ENSP00000414982

UniGene: Hs.20107

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