KLHL42 Antibody, HRP conjugated

Code CSB-PA885803LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KLHL42 Polyclonal antibody
Uniprot No.
Target Names
KLHL42
Alternative Names
KLHL42 antibody; KIAA1340 antibody; KLHDC5Kelch-like protein 42 antibody; Cullin-3-binding protein 9 antibody; Ctb9 antibody; Kelch domain-containing protein 5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Kelch-like protein 42 protein (1-410AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Gene References into Functions
  1. Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal PMID: 19261606
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.
Database Links

HGNC: 29252

KEGG: hsa:57542

STRING: 9606.ENSP00000370671

UniGene: Hs.505104

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