KYNU Antibody

Datasheet

Code	CSB-PA621970LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse spleen tissue All lanes: KYNU antibody at 3.4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 52, 35 kDa Observed band size: 52 kDa Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA621970LA01HU at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA621970LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KYNU Polyclonal antibody

Uniprot No.

Q16719

Target Names

KYNU

Alternative Names

kynU antibody; KYNU_HUMAN antibody; kynureninase (L-kynurenine hydrolase) antibody; Kynureninase antibody; L-kynurenine hydrolase antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Kynureninase protein (99-214AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KYNU Antibody (Product code: CSB-PA621970LA01HU) is Non-conjugated. For KYNU Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA621970LB01HU	KYNU Antibody, HRP conjugated	ELISA
FITC	CSB-PA621970LC01HU	KYNU Antibody, FITC conjugated
Biotin	CSB-PA621970LD01HU	KYNU Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Gene References into Functions

Our results suggest that tryptophan metabolism might dichotomously modulate immune responses, with KYNU as a switch between immunosuppressive versus inflammatory outcomes. PMID: 26725996
A rare variant at the KYNU gene is associated with essential hypertension in the Han Chinese population. PMID: 22012986
The Lys412Glu polymorphism of the KYNU gene in a hypertensive candidate chromosomal region is associated with essential hypertension in Han Chinese. PMID: 16080802

Involvement in disease

Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)

Subcellular Location

Cytoplasm, cytosol.

Protein Families

Kynureninase family

Tissue Specificity

Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.

Database Links

HGNC: 6469

OMIM: 236800

KEGG: hsa:8942

STRING: 9606.ENSP00000264170

UniGene: Hs.470126

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The Overview of Interferon Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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