KYNU Antibody

Datasheet

Code	CSB-PA621970ESR2HU
Size	US$166
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Image	Western blot All lanes: KYNU antibody at 1.44μg/ml Lane 1: A549 whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 53, 35 kDa Observed band size: 53 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA621970ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA621970ESR2HU at dilution of 1:100 Immunoprecipitating KYNU in Hela whole cell lysate Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA621970ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000) Lane 2: CSB-PA621970ESR2HU (4μg) + Hela whole cell lysate (500μg) Lane 3: Hela whole cell lysate (20μg)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KYNU Polyclonal antibody

Uniprot No.

Q16719

Target Names

KYNU

Alternative Names

kynU antibody; KYNU_HUMAN antibody; kynureninase (L-kynurenine hydrolase) antibody; Kynureninase antibody; L-kynurenine hydrolase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kynureninase protein (1-307AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC, IP

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IP	1:200-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

KYNU polyclonal antibody CSB-PA621970ESR2HU was produced in the rabbit immunized by using the Recombinant Human Kynureninase protein (1-307AA) as the immunogen. The target protein KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Diseases associated with KYNU include Hydroxykynureninuria and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2.
This Rabbit anti-Homo sapiens (Human) KYNU Polyclonal antibody was tested in the ELISA, WB, IHC and IP applications. The non-conjugated IgG got purified by antigen affinity. It only reacts with the KYNU proteins of human-origin and may be used to detect the endogenous levels of KYNU protein.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Gene References into Functions

Our results suggest that tryptophan metabolism might dichotomously modulate immune responses, with KYNU as a switch between immunosuppressive versus inflammatory outcomes. PMID: 26725996
A rare variant at the KYNU gene is associated with essential hypertension in the Han Chinese population. PMID: 22012986
The Lys412Glu polymorphism of the KYNU gene in a hypertensive candidate chromosomal region is associated with essential hypertension in Han Chinese. PMID: 16080802

Involvement in disease

Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)

Subcellular Location

Cytoplasm, cytosol.

Protein Families

Kynureninase family

Tissue Specificity

Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.

Database Links

HGNC: 6469

OMIM: 236800

KEGG: hsa:8942

STRING: 9606.ENSP00000264170

UniGene: Hs.470126

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