Kcne2 Antibody

Code CSB-PA012027LA01RA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Kcne2 Polyclonal antibody
Uniprot No.
Target Names
Kcne2
Alternative Names
Kcne2Potassium voltage-gated channel subfamily E member 2 antibody; MinK-related peptide 1 antibody; Minimum potassium ion channel-related peptide 1 antibody; Potassium channel subunit beta MiRP1 antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat Potassium voltage-gated channel subfamily E member 2 protein (1-123AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated

The Kcne2 Antibody (Product code: CSB-PA012027LA01RA) is Non-conjugated. For Kcne2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA012027LB01RA Kcne2 Antibody, HRP conjugated ELISA
FITC CSB-PA012027LC01RA Kcne2 Antibody, FITC conjugated
Biotin CSB-PA012027LD01RA Kcne2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current.
Gene References into Functions
  1. Endogenous KCNE2 in cardiomyocytes is important in maintaining cardiac electrical stability mainly by regulating Ito and action potential duration. PMID: 26297229
  2. The KCNE2 mutation R27C may induce familial atrial fibrillation partially through enhancing the suppression of Cav1.2 calcium channel. PMID: 24681347
  3. KCNE2 can modulate its partner channel function not only by altering channel conductance and/or gating kinetics, but also by affecting protein stability. PMID: 22180649
  4. KCNE-2 potassium channel and KCNH-2 are molecular subunits of an inwardly rectifying potassium channel complex. PMID: 19913309
  5. In aging rat ventricle, KCNE2 may associate with HCN2 and enhance its current amplitude. KCNE2 protein is expressed in ventricles, and it can play diverse roles in ventricular electrical activity under (patho)physiological conditions. PMID: 15066947
  6. MiRP1 acts as a beta subunit for HCN2 pacemaker channel subunits and alters channel gating at physiologically relevant voltages in cardiac cells. PMID: 15292247

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Potassium channel KCNE family
Tissue Specificity
Expressed in the heart.
Database Links
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