LAMB1 Antibody

Code CSB-PA003135
Size US$167
Image
  • Western Blot analysis of HepG2 cells using Laminin β-1 Polyclonal Antibody
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Product Details

Uniprot No. P07942
Target Names LAMB1
Alternative Names CLM antibody; Cutis laxa with marfanoid phenotype antibody; LAM B1 antibody; LAMB 1 antibody; LAMB1 antibody; LAMB1_HUMAN antibody; Laminin B1 antibody; Laminin B1 chain antibody; Laminin beta 1 chain antibody; Laminin beta 1 chain precursor antibody; Laminin beta1 antibody; Laminin subunit beta 1 antibody; Laminin subunit beta-1 antibody; Laminin-1 subunit beta antibody; Laminin-10 subunit beta antibody; Laminin-12 subunit beta antibody; Laminin-2 subunit beta antibody; Laminin-6 subunit beta antibody; Laminin-8 subunit beta antibody; LIS5 antibody; MGC142015 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the C-terminal region of Human Laminin β-1.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
Gene References into Functions
  1. High cytoplasmic laminin expression is associated with Oral Squamous Cell Carcinomas. PMID: 29479990
  2. Treatment of Neuroscreen-1 (NS-1) cells with laminin-1 or YIGSR peptide, which corresponds to a sequence in laminin-1 beta1 chain that binds to 67LR, induced a decrease in the cell-surface expression of 67LR and caused its internalization. PMID: 29108990
  3. In vitro activation of PDGFR-alpha leads to translational activation of LAMB1, which in turn induces an invasive and metastatic phenotype of hepatocellular carcinoma cells exhibiting K19 expression. PMID: 28783171
  4. LAMB1 may affect the initiation and progression of pneumoconiosis, or serve as a potential biomarker of pneumoconiosis for diagnosis and genetic susceptibility. PMID: 28444932
  5. LAMB1 is a potential serological biomarker that could be used in conjunction with carcinoembryonic antigen for diagnosis of colorectal cancer. PMID: 26359947
  6. These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway. PMID: 26057585
  7. An association was found between LAMB1 rs2158836 polymorphisms and symptom severity in Korean autism spectrum disorder patients. PMID: 25774865
  8. LAMB1 single nucleotide polymorphism rs886774 was associated with early onset Ulcerative colitis and, thus, suggests a fundamentally different mechanism of early disease pathogenesis in Ulcerative colitis versus Crohn's disease. PMID: 25664710
  9. Upregulation of LAMB1 expression was highly correlated with the downregulation of miR-124-5p. LAMB1 protein expression was suppressed by miR-124-5p. PMID: 24497408
  10. The phenotype due to LAMB2 mutations appears to be similar between different ethnic groups. PMID: 23679161
  11. Homozygous deleterious mutations in LAMB1. PMID: 23472759
  12. Laminin beta1 and integrin alpha2 expression is elevated in the anterior temporal neocortex tissue from patients with intractable epilepsy. PMID: 21370991
  13. We did not find an association of rs6949033 (LAMB1) with ulcerative colitis. PMID: 21744425
  14. mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions. PMID: 12615822
  15. alteration of LAMB1 expression is associated with the genesis and development of uterine leiomyoma PMID: 15706419
  16. laminin beta1 chain (a constituent of laminin-8) was typically found in vessel walls of carcinomas and their metastases but not in those of normal breast PMID: 15987446
  17. laminin supports platelet adhesion depending on the interaction of VWF and GPIb-IX-V under pathophysiological high shear flow PMID: 18450753
  18. Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix. PMID: 18474427
  19. Elevated expression of laminin beta1 mRNA and protein in the hippocampus suggests that laminin beta1 may play a role in the development of epileptic seizures in patients with intractable epilepsy. PMID: 18691630
  20. beta2 chain-containing laminins (beta2-laminins) bound more avidly to alpha3beta1 and alpha7X2beta1 integrins than beta1 chain-containing laminins (beta1-laminins). PMID: 19147489
  21. The presence of nuclear beta-catenin and high content of mmp-9 in the tumor were associated with abnormal accumulation of laminin in the cytoplasm. These changes were characteristic of colorectal cancer with high invasive metastatic potential. PMID: 19526105
  22. LAMB1 new susceptibility loci for ulcerative colitis PMID: 19915572

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Involvement in disease Lissencephaly 5 (LIS5)
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane
Database Links

HGNC: 6486

OMIM: 150240

KEGG: hsa:3912

STRING: 9606.ENSP00000222399

UniGene: Hs.650585

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