LANCL2 Antibody

Datasheet

Code	CSB-PA865129LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: A549 whole cell lysate, U87 whole cell lysate All lanes: LANCL2 antibody at 3.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 51 kDa Observed band size: 51 kDa IHC image of CSB-PA865129LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of HepG2 cells with CSB-PA865129LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LANCL2 Polyclonal antibody

Uniprot No.

Q9NS86

Target Names

LANCL2

Alternative Names

G protein coupled receptor 69B antibody; GPR69B antibody; LanC (bacterial lantibiotic synthetase component C) like 2 antibody; LanC-like protein 2 antibody; LANC2_HUMAN antibody; LANCL2 antibody; TASP antibody; Testis specific adriamycin sensitivity protein antibody; Testis-specific adriamycin sensitivity protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human LanC-like protein 2 protein (2-106AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LANCL2 Antibody (Product code: CSB-PA865129LA01HU) is Non-conjugated. For LANCL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA865129LB01HU	LANCL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA865129LC01HU	LANCL2 Antibody, FITC conjugated
Biotin	CSB-PA865129LD01HU	LANCL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Gene References into Functions

human LANCL2 is a non-transmembrane G protein-coupled receptor susceptible to hormone-induced nuclear translocation. PMID: 27222287
Data indicate that lanthionine synthetase C-like 2 (LanCL2) depletion sensitizes cells to apoptosis through down-regulating serine/threonine protein kinase Akt phosphorylation. PMID: 25273559
human recombinant LANCL2 binds abscisic acid (ABA) directly and provide the first demonstration of ABA binding to a mammalian ABA receptor. PMID: 22037458
Molecular docking studies predict that ABA and other PPAR gamma agonists (e.g., rosiglitazone and pioglitazone) share a binding site on the surface of LANCL2. PMID: 20512604
cDNA cloned and characterized. May play a role as a component of a peptide-modifying complex PMID: 11762191
Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. PMID: 12566319
Data show that lanthionine synthetase C-like protein (LANCL2) is required for abscisic acid binding on human granulocyte membranes and that LANCL2 is necessary for transduction of the ABA signal into granulocytes and rat insulinoma cells. PMID: 19667068

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Subcellular Location

Nucleus. Cytoplasm. Cell membrane.

Protein Families

LanC-like protein family

Tissue Specificity

Expressed in brain and testis.

Database Links

HGNC: 6509

OMIM: 612919

KEGG: hsa:55915

STRING: 9606.ENSP00000254770

UniGene: Hs.595384

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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