LMNB2 Antibody

1. our studies strongly implicate an overarching role for Lamin B2 in the maintenance of nuclear architecture since loss of Lamin B2 relieves the spatial positional constraints required for maintaining conserved localization of aneuploid chromosome territories in the interphase nucleus. PMID: 26921073
2. Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia. PMID: 25954030
3. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. PMID: 25477337
4. Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A and a decrease in mature lamin B1 PMID: 23475125
5. Mutation in LMNB2 gene is associated with partial lipodystrophy. PMID: 22768673
6. Studies indicate that the lamin-binding proteins implicated in laminopathies include lamin B2 and nuclear envelope proteins. PMID: 21400569
7. These findings indicate that a lamin dimer principally has the freedom for a "combinatorial" head-to-tail association with all types of lamins, a property that might be of significant importance for the assembly of the nuclear lamina. PMID: 20004208
8. analysis of protein-DNA interactions at the human lamin B2 replication origin PMID: 12902329
9. The proteins bound in vivo at the LMNB2 replication origin were investigated along the cell cycle. PMID: 12912926
10. This analysis reveals the modular structure of the lamin B2 origin and supports the idea that sequence elements close to the replication start site play an important role in origin activation. PMID: 15024083
11. the distinctive ensemble of heterotypic lamin interactions in a particular cell type affects the stability of the lamin polymer PMID: 15284226
12. the lamin B2 origin adopts a structure partly composed of intramolecular TAT triads PMID: 15611042
13. lamin B was essential for the formation of the mitotic matrix that tethers a number of spindle assembly factors; propose that lamin B is a structural component of the spindle matrix that promotes microtubule assembly and organization in mitosis PMID: 16543417
14. Three new rare heterozygous mutations are the first reported for LMNB2 and are the first reported among patients with acquired partial lipodystrophy. PMID: 16826530
15. human lamin B(2) is indeed synthesized as a longer version than previously reported, because it contains these additional 20 amino acids PMID: 17070523
16. The human DNA replication origin, located in the lamin B2 gene, interacts with the DNA topoisomerases I and II in a cell cycle-modulated manner. PMID: 17290216

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HGNC: 6638

OMIM: 150341

KEGG: hsa:84823

STRING: 9606.ENSP00000462730

UniGene: Hs.538286