LPO Antibody, HRP conjugated

Code CSB-PA013066LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LPO Polyclonal antibody
Uniprot No.
Target Names
LPO
Alternative Names
LPO antibody; SAPX antibody; Lactoperoxidase antibody; LPO antibody; EC 1.11.1.7 antibody; Salivary peroxidase antibody; SPO antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Lactoperoxidase protein (81-190AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May contribute to airway host defense against infection.
Gene References into Functions
  1. The crystal structure of the complex of LPO with MZY showed that MZY bound to LPO in the substrate-binding site on the distal heme side. MZY was oriented in the substrate-binding site in such a way that the sulfur atom is at a distance of 2.58 A from the heme iron PMID: 28653416
  2. LPO mRNA was undetectable in the gastric mucosa. PMID: 27048452
  3. Oral peroxidase activity as a marker of chronic alcohol abuse may help in the diagnosis of alcoholism. PMID: 23042278
  4. establish urate as a likely physiological substrate for LPO that will influence host defense and give rise to reactive electrophilic metabolites PMID: 24928513
  5. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
  6. a functional LPO system exists in human airways and may contribute to airway host defense against infection PMID: 12626341
  7. lactoperoxidase may play an important role in the metabolic events associated with Parkinson's disease PMID: 15384204
  8. Analysis of the role of thiocyanate (SCN-), in modulating the catalytic activity of myeloperoxidase (MPO) and other members of the lactoperoxidase (LPO) and eosinophil peroxidase (EPO) PMID: 15894800
  9. Splice variants may contribute to LPO molecular heterogeneity and its regulation by intracellular compartmental localization in respiratory epithelium. PMID: 19059195

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Subcellular Location
Secreted.
Protein Families
Peroxidase family, XPO subfamily
Tissue Specificity
Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.
Database Links

HGNC: 6678

OMIM: 150205

KEGG: hsa:4025

STRING: 9606.ENSP00000262290

UniGene: Hs.234742

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