LPO Antibody

Datasheet

Code	CSB-PA013066LA01HU
Size	US$166
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Image	IHC image of CSB-PA013066LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Western Blot Positive WB detected in: K562 whole cell lysate, HL60 whole cell lysate All lanes: LPO antibody at 5.1μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 81, 71 kDa Observed band size: 81 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LPO Polyclonal antibody

Uniprot No.

P22079

Target Names

LPO

Alternative Names

LPO antibody; SAPX antibody; Lactoperoxidase antibody; LPO antibody; EC 1.11.1.7 antibody; Salivary peroxidase antibody; SPO antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Lactoperoxidase protein (81-190AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LPO Antibody (Product code: CSB-PA013066LA01HU) is Non-conjugated. For LPO Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA013066LB01HU	LPO Antibody, HRP conjugated	ELISA
FITC	CSB-PA013066LC01HU	LPO Antibody, FITC conjugated
Biotin	CSB-PA013066LD01HU	LPO Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May contribute to airway host defense against infection.

Gene References into Functions

The crystal structure of the complex of LPO with MZY showed that MZY bound to LPO in the substrate-binding site on the distal heme side. MZY was oriented in the substrate-binding site in such a way that the sulfur atom is at a distance of 2.58 A from the heme iron PMID: 28653416
LPO mRNA was undetectable in the gastric mucosa. PMID: 27048452
Oral peroxidase activity as a marker of chronic alcohol abuse may help in the diagnosis of alcoholism. PMID: 23042278
establish urate as a likely physiological substrate for LPO that will influence host defense and give rise to reactive electrophilic metabolites PMID: 24928513
High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
a functional LPO system exists in human airways and may contribute to airway host defense against infection PMID: 12626341
lactoperoxidase may play an important role in the metabolic events associated with Parkinson's disease PMID: 15384204
Analysis of the role of thiocyanate (SCN-), in modulating the catalytic activity of myeloperoxidase (MPO) and other members of the lactoperoxidase (LPO) and eosinophil peroxidase (EPO) PMID: 15894800
Splice variants may contribute to LPO molecular heterogeneity and its regulation by intracellular compartmental localization in respiratory epithelium. PMID: 19059195

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Subcellular Location

Secreted.

Protein Families

Peroxidase family, XPO subfamily

Tissue Specificity

Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.

Database Links

HGNC: 6678

OMIM: 150205

KEGG: hsa:4025

STRING: 9606.ENSP00000262290

UniGene: Hs.234742

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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