LXN Antibody, Biotin conjugated

1. Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism. PMID: 28087740
2. Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells. PMID: 26530530
3. Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells. PMID: 25551472
4. latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues. PMID: 24399246
5. CD146 and Lxn increased tumor migration and invasion of thyroid cancer. PMID: 23712706
6. The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. PMID: 23364479
7. These results are consistent with a tumor suppressor role for latexin. PMID: 23028717
8. Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines. PMID: 21567403
9. downregulated expression in gastric carcinomas; tumor suppressor PMID: 21466706

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HGNC: 13347

OMIM: 609305

KEGG: hsa:56925

STRING: 9606.ENSP00000264265

UniGene: Hs.478067