LXN Antibody, FITC conjugated

Datasheet

Code	CSB-PA013240LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LXN Polyclonal antibody

Uniprot No.

Q9BS40

Target Names

LXN

Alternative Names

ECI antibody; Endogenous carboxypeptidase inhibitor antibody; Latexin antibody; Latexin protein antibody; LXN antibody; LXN_HUMAN antibody; MUM antibody; Protein MUM antibody; TCI antibody; Tissue carboxypeptidase inhibitor antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Latexin protein (1-216AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.

Gene References into Functions

Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism. PMID: 28087740
Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells. PMID: 26530530
Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells. PMID: 25551472
latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues. PMID: 24399246
CD146 and Lxn increased tumor migration and invasion of thyroid cancer. PMID: 23712706
The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. PMID: 23364479
These results are consistent with a tumor suppressor role for latexin. PMID: 23028717
Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines. PMID: 21567403
downregulated expression in gastric carcinomas; tumor suppressor PMID: 21466706

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Subcellular Location

Cytoplasm.

Protein Families

Protease inhibitor I47 (latexin) family

Tissue Specificity

Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.

Database Links

HGNC: 13347

OMIM: 609305

KEGG: hsa:56925

STRING: 9606.ENSP00000264265

UniGene: Hs.478067

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Protein Service

Gene Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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