Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA009885 |
| Size | US$167 |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Uniprot No. | Q16553 | ||||||
| Target Names | LY6E | ||||||
| Alternative Names | LY6E antibody; 9804 antibody; RIGE antibody; SCA2 antibody; TSA1 antibody; Lymphocyte antigen 6E antibody; Ly-6E antibody; Retinoic acid-induced gene E protein antibody; RIG-E antibody; Stem cell antigen 2 antibody; SCA-2 antibody; Thymic shared antigen 1 antibody; TSA-1 antibody | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human | ||||||
| Immunogen | Synthesized peptide derived from the Internal region of Human TSA-1. | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated | ||||||
| Isotype | IgG | ||||||
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||||||
| Form | Liquid | ||||||
| Tested Applications | IF, ELISA | ||||||
| Recommended Dilution |
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| Protocols | Immunofluorescence (IF) Protocol ELISA Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.; (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape.
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| Gene References into Functions |
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| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Specificity | Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes. |
| Database Links |
HGNC: 6727 OMIM: 601384 KEGG: hsa:4061 STRING: 9606.ENSP00000292494 UniGene: Hs.521903 |
