LZTFL1 Antibody

Code CSB-PA568879
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA568879(LZTFL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA568879(LZTFL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human testis tissue, 293T cells, A172 cells, Primary antibody: CSB-PA568879(LZTFL1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details

Uniprot No.
Target Names
LZTFL1
Alternative Names
5530402H04Rik antibody; 6130400H19Rik antibody; AI414725 antibody; AW048545 antibody; BBS17 antibody; DKFZp686H2076 antibody; FLJ36386 antibody; Leucine zipper transcription factor like 1 antibody; Leucine zipper transcription factor like protein 1 antibody; Leucine zipper transcription factor-like protein 1 antibody; LZTFL 1 antibody; Lztfl1 antibody; Lztfl1 leucine zipper transcription factor-like 1 antibody; LZTL1_HUMAN antibody; MGC106871 antibody; MGC108960 antibody; Putative uncharacterized protein DKFZp686H2076 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human LZTFL1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Gene References into Functions
  1. LZTFL1 inhibits lung tumorigenesis PMID: 26364604
  2. these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. PMID: 26700766
  3. LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation PMID: 25005785
  4. This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). PMID: 23692385
  5. The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). PMID: 22510444
  6. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling PMID: 22072986
  7. LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. PMID: 20233871

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Involvement in disease
Bardet-Biedl syndrome 17 (BBS17)
Subcellular Location
Cytoplasm.
Protein Families
LZTFL1 family
Tissue Specificity
Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, splee
Database Links

HGNC: 6741

OMIM: 606568

KEGG: hsa:54585

STRING: 9606.ENSP00000296135

UniGene: Hs.30824

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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