MAEL Antibody, FITC conjugated

1. MAEL promoter hypermethylation may have a role in de-repression of LINE-1 in human hypospermatogenesis PMID: 29095993
2. Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence. PMID: 27926513
3. Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1. PMID: 27181205
4. Study demonstrated that MAEL interacts with Snail and inhibit E-cadherin promoter activity. MAEL is an oncogene that plays an important role in the development and progression of colon cancer. PMID: 27537253
5. Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs. PMID: 24189637
6. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3beta/Snail signaling. PMID: 23929794
7. These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation. PMID: 19693694

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HGNC: 25929

OMIM: 611368

KEGG: hsa:84944

STRING: 9606.ENSP00000356846

UniGene: Hs.651245