MAN2A1 Antibody, HRP conjugated

Datasheet

Code	CSB-PA613697LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAN2A1 Polyclonal antibody

Uniprot No.

Q16706

Target Names

MAN2A1

Alternative Names

3-1 antibody; 6-alpha-mannosidase antibody; Alpha mannosidase 2 antibody; alpha Mannosidase II antibody; Alpha-mannosidase 2 antibody; AMAN II antibody; Golgi alpha mannosidase II antibody; Golgi alpha-mannosidase II antibody; Golgi integral membrane protein 7 antibody; GOLIM7 antibody; MA2A1_HUMAN antibody; MAN II antibody; Man2a1 antibody; MANA 2 antibody; MANA2 antibody; MANII antibody; Mann II antibody; Mannosidase alpha class 2A member 1 antibody; Mannosidase Two antibody; Mannosidase; alpha type II antibody; Mannosidase; alpha; II antibody; Mannosyl oligosaccharide 1 3 1 6 alpha mannosidase antibody; Mannosyl oligosaccharide 1,3 1,6 alpha mannosidase antibody; Mannosyl-oligosaccharide 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Alpha-mannosidase 2 protein (31-181AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Gene References into Functions

he QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and force field methods reached their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for GMII drug developments. PMID: 27035259
Many human tumor types and cancer cell lines express the MAN2A1-FER fusion, which increases proliferation and invasiveness of cancer cell lines and has liver oncogenic activity in mice. PMID: 28245430
The disruption of Golgi alpha-mannosidase II activity by swainsonine in human embryonic kidney cells is capable of inducing a novel class of hybrid-type glycosylation containing a partially processed mannose moiety. PMID: 17466984
This article discribes experiments in which the MAN2A1 homologue in mouse was deleted, resulting in a systemic autoimmune disease in the mice which is similar to human systemic lupus erythematosus. PMID: 11158608

Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyl hydrolase 38 family

Database Links

HGNC: 6824

OMIM: 154582

KEGG: hsa:4124

STRING: 9606.ENSP00000261483

UniGene: Hs.432822

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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