MAN2A1 Antibody

Datasheet

Code	CSB-PA613697LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate All lanes: MAN2A1 antibody at 3.5μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 132 kDa Observed band size: 150 kDa Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613697LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA613697LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA613697LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAN2A1 Polyclonal antibody

Uniprot No.

Q16706

Target Names

MAN2A1

Alternative Names

3-1 antibody; 6-alpha-mannosidase antibody; Alpha mannosidase 2 antibody; alpha Mannosidase II antibody; Alpha-mannosidase 2 antibody; AMAN II antibody; Golgi alpha mannosidase II antibody; Golgi alpha-mannosidase II antibody; Golgi integral membrane protein 7 antibody; GOLIM7 antibody; MA2A1_HUMAN antibody; MAN II antibody; Man2a1 antibody; MANA 2 antibody; MANA2 antibody; MANII antibody; Mann II antibody; Mannosidase alpha class 2A member 1 antibody; Mannosidase Two antibody; Mannosidase; alpha type II antibody; Mannosidase; alpha; II antibody; Mannosyl oligosaccharide 1 3 1 6 alpha mannosidase antibody; Mannosyl oligosaccharide 1,3 1,6 alpha mannosidase antibody; Mannosyl-oligosaccharide 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Alpha-mannosidase 2 protein (31-181AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MAN2A1 Antibody (Product code: CSB-PA613697LA01HU) is Non-conjugated. For MAN2A1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA613697LB01HU	MAN2A1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613697LC01HU	MAN2A1 Antibody, FITC conjugated
Biotin	CSB-PA613697LD01HU	MAN2A1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Gene References into Functions

he QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and force field methods reached their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for GMII drug developments. PMID: 27035259
Many human tumor types and cancer cell lines express the MAN2A1-FER fusion, which increases proliferation and invasiveness of cancer cell lines and has liver oncogenic activity in mice. PMID: 28245430
The disruption of Golgi alpha-mannosidase II activity by swainsonine in human embryonic kidney cells is capable of inducing a novel class of hybrid-type glycosylation containing a partially processed mannose moiety. PMID: 17466984
This article discribes experiments in which the MAN2A1 homologue in mouse was deleted, resulting in a systemic autoimmune disease in the mice which is similar to human systemic lupus erythematosus. PMID: 11158608

Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyl hydrolase 38 family

Database Links

HGNC: 6824

OMIM: 154582

KEGG: hsa:4124

STRING: 9606.ENSP00000261483

UniGene: Hs.432822

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Lysosomal Enzymes and Lysosomal Storage Disorders (LSDs) The Overview of Organelles Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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