MAP1LC3C Antibody, FITC conjugated

Datasheet

Code	CSB-PA887153LC01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAP1LC3C Polyclonal antibody

Uniprot No.

Q9BXW4

Target Names

MAP1LC3C

Alternative Names

ATG8J antibody; Autophagy-related protein LC3 C antibody; Autophagy-related ubiquitin-like modifier LC3 C antibody; LC3 like protein 2 antibody; MAP1 light chain 3 like protein 2 antibody; MAP1 light chain 3 like protein 3 antibody; MAP1 light chain 3-like protein 3 antibody; MAP1A/MAP1B LC3 C antibody; MAP1A/MAP1B light chain 3 C antibody; MAP1LC3C antibody; Microtubule-associated protein 1 light chain 3 gamma antibody; Microtubule-associated proteins 1A/1B light chain 3C antibody; MLP3C_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Microtubule-associated proteins 1A/1B light chain 3C protein (1-30AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.

Gene References into Functions

a basal, housekeeping mitophagy pathway that involves piecemeal degradation of mitochondrial proteins in a LC3C- and p62-dependent manner and contributes to mitochondrial homeostasis maintenance when cells rely on oxidative phosphorylation. PMID: 29149599
a non-canonical autophagy pathway reminiscent of LC3-associated phagocytosis contributes to Vpu counteraction of BST2 restriction. PMID: 27880899
The WDR81 interacts with LC3C through canonical LC3-interacting regions in the BEACH domain, promoting LC3C recruitment to ubiquitinated proteins. PMID: 28404643
Results indicate that TECPR2 Binds LC3and the complex is required for autophagosome formation, possibly through regulation of functional ER exit sites PMID: 26431026
both autophagy-related 5 and microtubule-associated protein 1 light chain 3B levels are decreased in patients with melanomas as compared with those with benign nevi PMID: 24300435
ccytoplasm against Salmonella. PMID: 23022382

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Subcellular Location

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.

Protein Families

ATG8 family

Tissue Specificity

Most abundant in placenta, lung and ovary.

Database Links

HGNC: 13353

OMIM: 609605

KEGG: hsa:440738

STRING: 9606.ENSP00000349785

UniGene: Hs.534971

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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