Product Details

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

MAP1LC3C

Uniprot No.

Q9BXW4

Research Area

Cancer

Alternative Names

ATG8J; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; LC3 like protein 2; MAP1 light chain 3 like protein 2; MAP1 light chain 3 like protein 3; MAP1 light chain 3-like protein 3; MAP1A/MAP1B LC3 C; MAP1A/MAP1B light chain 3 C; MAP1LC3C; Microtubule-associated protein 1 light chain 3 gamma; Microtubule-associated proteins 1A/1B light chain 3C; MLP3C_HUMAN

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

1-126aa

Target Protein Sequence

MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

20.7 kDa

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Tris-based buffer,50% glycerol

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

Amino acids 1-126 constitute the expression domain of recombinant Human MAP1LC3C. The calculated molecular weight for this MAP1LC3C protein is 20.7 kDa. The MAP1LC3C protein was expressed in e.coli. The N-terminal 10xHis tag was fused into the coding gene segment of MAP1LC3C, making it easier to detect and purify the MAP1LC3C recombinant protein in the later stages of expression and purification.

The human microtubule-associated protein 1A/1B light chain 3C (MAP1MAP1LC3C) is a member of the LC3 family and functions in the formation of autophagosomes, which are essential structures in autophagy, a cellular process responsible for degrading and recycling cellular components. MAP1LC3C undergoes lipidation, facilitating its association with autophagosomal membranes. Its involvement in autophagy allows for the targeted removal of damaged or obsolete cellular constituents. Research on MAP1LC3C focuses on understanding its precise role in autophagic processes, its regulation, and its implications in various physiological and pathological conditions, including neurodegenerative diseases and cancer.

Target Background

Function

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.

Gene References into Functions

a basal, housekeeping mitophagy pathway that involves piecemeal degradation of mitochondrial proteins in a LC3C- and p62-dependent manner and contributes to mitochondrial homeostasis maintenance when cells rely on oxidative phosphorylation. PMID: 29149599
a non-canonical autophagy pathway reminiscent of LC3-associated phagocytosis contributes to Vpu counteraction of BST2 restriction. PMID: 27880899
The WDR81 interacts with LC3C through canonical LC3-interacting regions in the BEACH domain, promoting LC3C recruitment to ubiquitinated proteins. PMID: 28404643
Results indicate that TECPR2 Binds LC3and the complex is required for autophagosome formation, possibly through regulation of functional ER exit sites PMID: 26431026
both autophagy-related 5 and microtubule-associated protein 1 light chain 3B levels are decreased in patients with melanomas as compared with those with benign nevi PMID: 24300435
ccytoplasm against Salmonella. PMID: 23022382

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Subcellular Location

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.

Protein Families

ATG8 family

Tissue Specificity

Most abundant in placenta, lung and ovary.

Database Links

HGNC: 13353

OMIM: 609605

KEGG: hsa:440738

STRING: 9606.ENSP00000349785

UniGene: Hs.534971

Code	CSB-EP887153HU
Abbreviation	Recombinant Human MAP1LC3C protein
MSDS	MSDS Datasheet
Size	US$306
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C)

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