MATK Antibody

Code CSB-PA013519ESR1HU
Size US$166
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  • Western blot
    All lanes: MATK antibody at 5.06µg/ml
    Lane 1: MCF-7 whole cell lysate
    Lane 2: Hela whole cell lysate
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 57, 52 kDa
    Observed band size: 52 kDa

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA013519ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013519ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MATK Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CHK antibody; Csk homologous kinase antibody; Csk type protein tyrosine kinase antibody; CTK antibody; DKFZp434N1212 antibody; EC antibody; Hematopoietic consensus tyrosine lacking kinase antibody; Hematopoietic consensus tyrosine-lacking kinase antibody; HHYLTK antibody; Hydroxyaryl protein kinase antibody; HYL antibody; HYL tyrosine kinase antibody; HYLTK antibody; Leukocyte carboxyl terminal src kinase related antibody; Lsk antibody; matK antibody; MATK_HUMAN antibody; Megakaryocyte associated tyrosine kinase antibody; Megakaryocyte associated tyrosine protein kinase antibody; Megakaryocyte-associated tyrosine-protein kinase antibody; MGC1708 antibody; MGC2101 antibody; Protein kinase HYL antibody; Tyrosine kinase MATK antibody; Tyrosine protein kinase CTK antibody; Tyrosine-protein kinase CTK antibody; Tyrosylprotein kinase antibody
Raised in
Species Reactivity
Recombinant Human Megakaryocyte-associated tyrosine-protein kinase protein (393-507AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Gene References into Functions
  1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1. PMID: 21799000
  2. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines PMID: 12122014
  3. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms PMID: 12429987
  4. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase PMID: 12782282
  5. Loss of CHK expression is associated with human brain tumors PMID: 15329911
  6. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation. PMID: 15748901
  7. striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains PMID: 15890649
  8. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells. PMID: 16168623
  9. Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses PMID: 16574955
  10. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation. PMID: 16707123
  11. Progesterone increases MATK in mast cells and reducs cell proliferation. PMID: 17492661
  12. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells. PMID: 17934522
  13. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma. PMID: 18292939

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Subcellular Location
Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, CSK subfamily
Tissue Specificity
Expressed in various myeloid cell lines, detected in brain and lung.
Database Links

HGNC: 6906

OMIM: 600038

KEGG: hsa:4145

STRING: 9606.ENSP00000378485

UniGene: Hs.631845

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