MATK Antibody

1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1. PMID: 21799000
2. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines PMID: 12122014
3. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms PMID: 12429987
4. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase PMID: 12782282
5. Loss of CHK expression is associated with human brain tumors PMID: 15329911
6. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation. PMID: 15748901
7. striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains PMID: 15890649
8. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells. PMID: 16168623
9. Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses PMID: 16574955
10. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation. PMID: 16707123
11. Progesterone increases MATK in mast cells and reducs cell proliferation. PMID: 17492661
12. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells. PMID: 17934522
13. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma. PMID: 18292939

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HGNC: 6906

OMIM: 600038

KEGG: hsa:4145

STRING: 9606.ENSP00000378485

UniGene: Hs.631845