MFNG Antibody, Biotin conjugated

Code CSB-PA013757LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MFNG Polyclonal antibody
Uniprot No.
Target Names
MFNG
Alternative Names
MFNG; Beta-1,3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Beta-1,3-N-acetylglucosaminyltransferase manic fringe protein (28-321AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.
Gene References into Functions
  1. MFNG imposes a negative correlation between Jag1 and Notch, being high Jag1 in the absence of MFNG predictive of poor prognosis. PMID: 30065304
  2. Mfng is an oncogene acting through Notch-mediated induction of Pik3cg. PMID: 25808869
  3. down regulated in Papillomavirus-mediated cervical neoplasia. PMID: 15280477
Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 31 family
Database Links

HGNC: 7038

OMIM: 602577

KEGG: hsa:4242

STRING: 9606.ENSP00000349490

UniGene: Hs.517603

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