MPC2 Antibody

Code CSB-PA002816LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Mouse kidney tissue
    All lanes: MPC2 antibody at 3.4μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 15 kDa
    Observed band size: 15 kDa

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA002816LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA002816LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MPC2 Polyclonal antibody
Uniprot No.
Target Names
MPC2
Alternative Names
MPC2; BRP44; Mitochondrial pyruvate carrier 2; Brain protein 44
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Mitochondrial pyruvate carrier 2 protein (1-40AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MPC2 Antibody (Product code: CSB-PA002816LA01HU) is Non-conjugated. For MPC2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA002816LB01HU MPC2 Antibody, HRP conjugated ELISA
FITC CSB-PA002816LC01HU MPC2 Antibody, FITC conjugated
Biotin CSB-PA002816LD01HU MPC2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates the uptake of pyruvate into mitochondria.
Gene References into Functions
  1. Hypoxia induces lactate secretion and glycolytic efflux by downregulating MPC1/MPC2 levels in HUVEC cells. PMID: 29845198
  2. Our study indicates that MPC1 and MPC2 expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 is a predictor of favorable outcome. PMID: 27852261
  3. a significant association between MPC2 variant rs10489202 and Schizophrenia susceptibility in Han Chinese (Meta-Analysis) PMID: 27460766
  4. Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA formation. PMID: 28263840
  5. Tumor cells expressing MPC1 and MPC2 display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture. PMID: 25458841
  6. found no significant difference (P > 0.05) in either allele or genotype frequency in the SNPs between patients and controls. PMID: 23933155
  7. characterization of the rat ortholog PMID: 3022128

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Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
Database Links

HGNC: 24515

OMIM: 614737

KEGG: hsa:25874

STRING: 9606.ENSP00000271373

UniGene: Hs.517768

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