MPC2 Antibody

Datasheet

Code	CSB-PA002816GA01HU
Size	US$685
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Product Details

Uniprot No.	O95563
Target Names	MPC2
Alternative Names	0610006C01Rik antibody; 2010002I07Rik, antibody; 2610205H19Rik antibody; AA108335 antibody; BR44_HUMAN antibody; Brain protein 44 antibody; BRP44 antibody; DKFZp564B167 antibody; ESTM43 antibody; MGC125752 antibody; MGC125753 antibody; rCG_46381 antibody; RGD1563422 antibody; RP1-295C6.1 antibody
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat
Immunogen	Human BRP44-Specific
Immunogen Species	Homo sapiens (Human)
Isotype	IgG
Purification Method	Antigen Affinity purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications	ELISA,WB
Protocols	ELISA Protocol Western Blotting(WB) Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Function	Mediates the uptake of pyruvate into mitochondria.
Gene References into Functions	Hypoxia induces lactate secretion and glycolytic efflux by downregulating MPC1/MPC2 levels in HUVEC cells. PMID: 29845198 Our study indicates that MPC1 and MPC2 expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 is a predictor of favorable outcome. PMID: 27852261 a significant association between MPC2 variant rs10489202 and Schizophrenia susceptibility in Han Chinese (Meta-Analysis) PMID: 27460766 Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA formation. PMID: 28263840 Tumor cells expressing MPC1 and MPC2 display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture. PMID: 25458841 found no significant difference (P > 0.05) in either allele or genotype frequency in the SNPs between patients and controls. PMID: 23933155 characterization of the rat ortholog PMID: 3022128 Show More Hide All
Subcellular Location	Mitochondrion inner membrane, Multi-pass membrane protein
Protein Families	Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
Database Links	HGNC: 24515 OMIM: 614737 KEGG: hsa:25874 STRING: 9606.ENSP00000271373 UniGene: Hs.517768

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