MPC2 Antibody

Code CSB-PA002816GA01HU
Size US$685
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Product Details

Uniprot No. O95563
Target Names MPC2
Alternative Names 0610006C01Rik antibody; 2010002I07Rik, antibody; 2610205H19Rik antibody; AA108335 antibody; BR44_HUMAN antibody; Brain protein 44 antibody; BRP44 antibody; DKFZp564B167 antibody; ESTM43 antibody; MGC125752 antibody; MGC125753 antibody; rCG_46381 antibody; RGD1563422 antibody; RP1-295C6.1 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human BRP44-Specific
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Mediates the uptake of pyruvate into mitochondria.
Gene References into Functions
  1. Hypoxia induces lactate secretion and glycolytic efflux by downregulating MPC1/MPC2 levels in HUVEC cells. PMID: 29845198
  2. Our study indicates that MPC1 and MPC2 expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 is a predictor of favorable outcome. PMID: 27852261
  3. a significant association between MPC2 variant rs10489202 and Schizophrenia susceptibility in Han Chinese (Meta-Analysis) PMID: 27460766
  4. Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA formation. PMID: 28263840
  5. Tumor cells expressing MPC1 and MPC2 display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture. PMID: 25458841
  6. found no significant difference (P > 0.05) in either allele or genotype frequency in the SNPs between patients and controls. PMID: 23933155
  7. characterization of the rat ortholog PMID: 3022128

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Subcellular Location Mitochondrion inner membrane, Multi-pass membrane protein
Protein Families Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
Database Links

HGNC: 24515

OMIM: 614737

KEGG: hsa:25874

STRING: 9606.ENSP00000271373

UniGene: Hs.517768

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