MRC2 Antibody

1. Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2). PMID: 29061505
2. results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family PMID: 27247422
3. A model of the ligand-binding region of uPARAP was obtained by molecular replacement. PMID: 26527274
4. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript. PMID: 26284904
5. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma PMID: 26466547
6. Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates. PMID: 25381222
7. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression. PMID: 25408555
8. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid PMID: 24161566
9. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging. PMID: 23433549
10. TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. PMID: 22072289
11. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. PMID: 21768090
12. Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement PMID: 20845060
13. fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion PMID: 20339555
14. Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity. PMID: 19861500
15. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor PMID: 11903048
16. Endo180 was found to be distinct within the mannose receptor family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes PMID: 12068012
17. Mannose receptor activity is up-regulated by surfactant protein A on monocyte-derived macrophages. PMID: 12244146
18. characterization of the monosaccharide binding sites PMID: 12399458
19. Approximately 60% of the initial association of HIV with macrophages that lack expression of DC-SIGN (a dendritic cell-specific ICAM-3 receptor/HIV-1-binding protein) is mediated by the macrophage mannose receptor. PMID: 12645947
20. Results suggest that Endo180 is a crucial link between urokinase-type plasminogen activator and its receptor and setting of the internal cellular compass. PMID: 12952933
21. Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis PMID: 12972549
22. Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen. PMID: 17189524
23. To investigate the consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice; expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, showed enhanced tumor growth. PMID: 17974964
24. By using cell isolates from uPARAP deficient mice, it is demonstrated that uPARAP is a collagen receptor. Thus uPARAP deficient fibroblasts can not internalize collagen and show a reduced adhesion/migration on collagen surfaces PMID: 12668656

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HGNC: 16875

OMIM: 612264

KEGG: hsa:9902

STRING: 9606.ENSP00000307513

UniGene: Hs.7835