MS4A2 Antibody, HRP conjugated

Code CSB-PA015013LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) MS4A2 Polyclonal antibody
Uniprot No. Q01362
Target Names MS4A2
Alternative Names APY antibody; ATOPY antibody; Fc epsilon receptor I beta-chain antibody; Fc IgE receptor beta chain antibody; FCER1B antibody; FCERB_HUMAN antibody; FcERI antibody; High affinity immunoglobulin epsilon receptor subunit beta antibody; IgE Fc receptor subunit beta antibody; IGEL antibody; IGHER antibody; Membrane-spanning 4-domains subfamily A member 2 antibody; MS4A1 antibody; Ms4a2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human High affinity immunoglobulin epsilon receptor subunit beta protein (1-59AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Gene References into Functions
  1. Using immunohistochemistry, we validated that MS4A2, the beta subunit of the IgE receptor expressed on mast cells, is a favorable prognostic indicator and show that MS4A2 gene expression is an independent prognostic marker for early-stage lung cancer patient survival. PMID: 28775209
  2. in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels. PMID: 26792385
  3. study found a difference in the frequencies of genotypes of FcvarepsilonRIbeta subunit int 2 in allergic rhinitis patients and controls. The FcvarepsilonRIbeta subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort PMID: 24981302
  4. MS4A2 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
  5. no association between gene polymorphism and chronic spontaneous urticaria in Kashmiri population PMID: 24953255
  6. FcepsilonRIbeta -109C/T and IFN-gamma 874T/A polymorphisms may be influencing factors for asthma in the Asian population PMID: 25530133
  7. The results explain how initial membrane interactions of clustered IgE-Fcepsilon RI complexes lead to downstream cellular responses. PMID: 25658351
  8. Data indicated that the MS4A2 gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians. PMID: 24495860
  9. Cytoplasmic FcepsilonRIbeta, which is not co-localized with FcepsilonRIalpha, may function as a negative regulator, as it can capture important signalling molecules such as Lyn. PMID: 24118172
  10. t-FcepsilonRIbeta mediates Ca2+ -dependent microtubule formation, which promotes degranulation and cytokine release. PMID: 23643722
  11. The interaction between Lyn and FcepsilonRIbeta is indispensable for FcepsilonRI-mediated human mast cell activation. PMID: 22845063
  12. Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis. PMID: 22150093
  13. Polymorphisms in the Fc epsilon R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways in asthmatic patients. PMID: 19288130
  14. No associations with total and specific IgE levels as well as allergic sensitization were seen for FCER1B and FCER1G PMID: 20028371
  15. Methylation levels at the AluSp repeat analysed in MS4A2 were inconsistent with classical imprinting mechanisms and did not associate with atopy status PMID: 19796196
  16. Significant associations of single nucleotide polymorphisms with wheeze in the past year were detected in only four genes (IL4R, TLR4, MS4A2, TLR9). Variants in IL4R and TLR4 were also related to allergen-specific IgE, but not for MS4A2 and TLR9. PMID: 20085599
  17. Gene expression profiling after stimulation via high-affinity Fcepsilon receptor I (FcepsilonRI), showed the transcriptional levels of several CC chemokines were markedly increased. PMID: 12393595
  18. Products of the beta gene may control the level of surface expression, influencing susceptibility to allergies. PMID: 12753743
  19. The data suggested that the Gly237Gly genotype of the Fc epsilon RI beta gene conferred genetic susceptibility to allergic asthma in Chinese, which affected the total plasma IgE levels in the allergic asthma patients. PMID: 12903039
  20. A statistically significant association was foundbetween atopy and FcERIint2 variant polymorphism FcERIint2 polymorphism is related to atopy and may influence its development. PMID: 15087090
  21. The genomic region encompassing the beta-chain has been linked to atopy and a number of polymorphisms within the FcepsilonRIbeta gene are associated with various atopic diseases. PMID: 15316148
  22. FcepsilonRI beta-chain gene expression is down-regulated by a transcription factor, MZF-1, adn its cofactor FHL-3. PMID: 15453830
  23. Single nucleotide polymorphisms (SNPs) in the Fc epsilon receptor I beta promoter are causally linked with atopy via regulation of Fc epsilon RI expression. PMID: 15528387
  24. The speed of allergic symptom generation depends on the degree of IgE Fc epsilon receptor type I receptor triggering. PMID: 17088130
  25. in the Korean general population, airway hyper-responsiveness is significantly associated with the E237G polymorphism of FcepsilonRI-beta, which results in an intolerant amino acid substitution PMID: 17430357
  26. FcepsilonRIbeta E237G allele may have a protective role in wheezing illness among Taiwanese schoolchildren, depending on airway oxidative stress levels. PMID: 18269668
  27. The -237T>G polymorphism may be associated with the rate of atopy, which in turn could increase the release of histamine from basophils and may lead to the development of the aspirin-intolerant chronic urticaria PMID: 18534082
  28. PLSCR1 is a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses PMID: 18579528
  29. Fcgr4 is a mouse IgE receptor that resembles macrophage MS4A2 protein in humans and promotes IgE-induced lung inflammation. PMID: 18949059
  30. A promoter-dependent mechanism with altered transcriptional regulation of FcepsilonRIbeta may be involved for its association with asthma. PMID: 19218813

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families MS4A family
Tissue Specificity Found on the surface of mast cells and basophils.
Database Links

HGNC: 7316

OMIM: 147138

KEGG: hsa:2206

STRING: 9606.ENSP00000278888

UniGene: Hs.386748

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