MYH14 Antibody

Code CSB-PA773786LA01HU
Size US$166
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Image
  • IHC image of CSB-PA773786LA01HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA773786LA01HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated ABC system.

  • Immunofluorescence staining of MCF-7 cells with CSB-PA773786LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MYH14 Polyclonal antibody
Uniprot No.
Target Names
MYH14
Alternative Names
2400004E04Rik antibody; DFNA4 antibody; DKFZp667A1311 antibody; FLJ13881 antibody; FLJ43092 antibody; FP17425 antibody; II C antibody; KIAA2034 antibody; MHC16 antibody; Myh 14 antibody; MYH14 antibody; MYH14_HUMAN antibody; Myosin 14 antibody; Myosin antibody; Myosin heavy chain 14 antibody; Myosin heavy chain antibody; Myosin heavy chain non muscle IIc antibody; Myosin heavy polypeptide 14 antibody; Myosin-14 antibody; NMHC II C antibody; NMHC II-C antibody; Non muscle myosin heavy chain IIc antibody; non-muscle IIc antibody; Non-muscle myosin heavy chain IIc antibody; Nonmuscle myosin heavy chain II C antibody; OTTMUSP00000019210 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Myosin-14 protein (1058-1195AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MYH14 Antibody (Product code: CSB-PA773786LA01HU) is Non-conjugated. For MYH14 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA773786LB01HU MYH14 Antibody, HRP conjugated ELISA
FITC CSB-PA773786LC01HU MYH14 Antibody, FITC conjugated
Biotin CSB-PA773786LD01HU MYH14 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Gene References into Functions
  1. This is the first identification of mutations in MYH14 as a cause of Anorectal malformations. PMID: 28191911
  2. By reporting two novel variants of MYH14, we suggest that the present study extends the phenotypic spectrum of autosomal dominant MYH14 variants to include nonsyndromic, severe-to-profound hearing loss with prelingual onset. PMID: 28221712
  3. phosphorylation of human cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice PMID: 26124132
  4. The data show that although NM IIA and IIB form filaments with similar properties, NM IIC forms filaments that are less well suited to roles such as tension maintenance within the cell. PMID: 24072716
  5. Results support the hypothesis that there is another DFNA gene upstream of the MYH14 gene and it may be linked to the DFNA4 locus. PMID: 23273769
  6. the alterations of the MYH14 gene may contribute to Myotonic dystrophy type 1 molecular pathogenesis. PMID: 21872659
  7. A complex phenotype of peripheral neuropathy, myopathy, hoarseness, and hearing loss is linked to an autosomal dominant mutation in MYH14 PMID: 21480433
  8. kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms PMID: 21478157
  9. data identify CEACAM16 as an alpha-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus PMID: 21368133
  10. Mutation in MYH14 gene can cause dominant non-syndromic hearing impairment in Asian population, suggesting that MYH14 gene can be a disease-causing gene of Chinese patients with hearing impairment. PMID: 20533261
  11. mutational screening in a large series of 300 hearing-impaired patients from Italy, Spain, and Belgium and in a German kindred linked to DFNA4 PMID: 15015131
  12. mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C PMID: 15845534
  13. data do not support the involvement of MYH14 in cleft lip and palate among the Italian population PMID: 18471249
  14. the alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation PMID: 19240025

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Involvement in disease
Deafness, autosomal dominant, 4A (DFNA4A); Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH)
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Tissue Specificity
High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No
Database Links

HGNC: 23212

OMIM: 600652

KEGG: hsa:79784

STRING: 9606.ENSP00000262269

UniGene: Hs.467142

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