MYO1E Antibody

Datasheet

Code	CSB-PA621526LA01HU
Size	US$166
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Image	IHC image of CSB-PA621526LA01HU diluted at 1:700 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA621526LA01HU diluted at 1:700 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MYO1E Polyclonal antibody

Uniprot No.

Q12965

Target Names

MYO1E

Alternative Names

FSGS6 antibody; HuncM-IC antibody; MYO1C antibody; Myo1e antibody; MYO1E variant protein antibody; MYO1E_HUMAN antibody; Myosin heavy chain myr 3 antibody; Myosin IC, formerly antibody; Myosin IE antibody; Myosin-Ic antibody; Myr 3 antibody; Myr3 antibody; MYR5 antibody; Unconventional myosin 1E antibody; Unconventional myosin Ie antibody; Unconventional myosin-Ie antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Unconventional myosin-Ie protein (62-189AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MYO1E Antibody (Product code: CSB-PA621526LA01HU) is Non-conjugated. For MYO1E Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA621526LB01HU	MYO1E Antibody, HRP conjugated	ELISA
FITC	CSB-PA621526LC01HU	MYO1E Antibody, FITC conjugated
Biotin	CSB-PA621526LD01HU	MYO1E Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.

Gene References into Functions

our data suggests that MYO1E contributes to breast tumor malignancy and regulates the differentiation and proliferation state of breast tumor cells. PMID: 27329840
The ERK signaling pathway thus promotes cell motility through regulation of the subcellular localization of Myo1E. PMID: 27502487
Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease. PMID: 25739341
Myo1e is a key component contributing to the functional integrity of podocytes. PMID: 23977349
MYO1E mutations are not a major cause of Chinese familial Steroid-resistant nephrotic syndrome. PMID: 24750828
Homozygosity mapping and exome sequencing in a consanguineous kindred identified MYO1E and NEIL1 as novel candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome. PMID: 21697813
MYO1E mutations are associated with childhood-onset, glucocorticoid-resistant focal segmental glomerulosclerosis. PMID: 21756023
myo1e binds lipids through nonspecific electrostatic interactions rather than a stereospecific protein-phosphoinositide interaction. PMID: 20860408
The kinetic mechanism of Myo1e (human myosin-IC). PMID: 11940582
Two proteins with prominent functions in endocytosis, synaptojanin-1 and dynamin, bind to the SH3 domain of human Myo1E. PMID: 17257598

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Involvement in disease

Focal segmental glomerulosclerosis 6 (FSGS6)

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction.

Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Tissue Specificity

Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes.

Database Links

HGNC: 7599

OMIM: 601479

KEGG: hsa:4643

STRING: 9606.ENSP00000288235

UniGene: Hs.654506

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Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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