MYO1E Antibody, FITC conjugated

Code CSB-PA621526LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MYO1E Polyclonal antibody
Uniprot No.
Target Names
MYO1E
Alternative Names
FSGS6 antibody; HuncM-IC antibody; MYO1C antibody; Myo1e antibody; MYO1E variant protein antibody; MYO1E_HUMAN antibody; Myosin heavy chain myr 3 antibody; Myosin IC, formerly antibody; Myosin IE antibody; Myosin-Ic antibody; Myr 3 antibody; Myr3 antibody; MYR5 antibody; Unconventional myosin 1E antibody; Unconventional myosin Ie antibody; Unconventional myosin-Ie antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Unconventional myosin-Ie protein (62-189AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
Gene References into Functions
  1. our data suggests that MYO1E contributes to breast tumor malignancy and regulates the differentiation and proliferation state of breast tumor cells. PMID: 27329840
  2. The ERK signaling pathway thus promotes cell motility through regulation of the subcellular localization of Myo1E. PMID: 27502487
  3. Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease. PMID: 25739341
  4. Myo1e is a key component contributing to the functional integrity of podocytes. PMID: 23977349
  5. MYO1E mutations are not a major cause of Chinese familial Steroid-resistant nephrotic syndrome. PMID: 24750828
  6. Homozygosity mapping and exome sequencing in a consanguineous kindred identified MYO1E and NEIL1 as novel candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome. PMID: 21697813
  7. MYO1E mutations are associated with childhood-onset, glucocorticoid-resistant focal segmental glomerulosclerosis. PMID: 21756023
  8. myo1e binds lipids through nonspecific electrostatic interactions rather than a stereospecific protein-phosphoinositide interaction. PMID: 20860408
  9. The kinetic mechanism of Myo1e (human myosin-IC). PMID: 11940582
  10. Two proteins with prominent functions in endocytosis, synaptojanin-1 and dynamin, bind to the SH3 domain of human Myo1E. PMID: 17257598

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Involvement in disease
Focal segmental glomerulosclerosis 6 (FSGS6)
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Tissue Specificity
Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes.
Database Links

HGNC: 7599

OMIM: 601479

KEGG: hsa:4643

STRING: 9606.ENSP00000288235

UniGene: Hs.654506

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