MYT1 Antibody

Datasheet

Code	CSB-PA015387LA01HU
Size	US$166
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Image	IHC image of CSB-PA015387LA01HU diluted at 1:300 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MYT1 Polyclonal antibody

Uniprot No.

Q01538

Target Names

MYT1

Alternative Names

C20orf36 antibody; KIAA0835 antibody; KIAA1050 antibody; MTF1 antibody; Myelin transcription factor 1 antibody; Myelin transcription factor I antibody; MYT1 antibody; MYT1_HUMAN antibody; MyTI antibody; PLPB1 antibody; Proteolipid protein-binding protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Myelin transcription factor 1 protein (317-451AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MYT1 Antibody (Product code: CSB-PA015387LA01HU) is Non-conjugated. For MYT1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA015387LB01HU	MYT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA015387LC01HU	MYT1 Antibody, FITC conjugated
Biotin	CSB-PA015387LD01HU	MYT1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

Gene References into Functions

A novel missense variant affecting function, c.323C>T (p.(Ser108Leu)), was identified in MYT1, in a patient presenting with a severe form of OAVS. MYT1 overexpression downregulated all RA receptors genes in vitro. PMID: 28612832
although depletion of MYT1 alone did not affect long-term cell growth, it potentiated with DNA damage to inhibit cell growth in clonogenic survival and tumor xenograft models PMID: 23146904
present in brain in infancy and prenatally in infants with periventricular leukomalacia PMID: 12524179
These results suggesta potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination. PMID: 17330875
UVA-induced caspase-3 cleavage and DNA fragmentation were suppressed by the knockdown of human Myt1 in skin cancer cells. PMID: 19204086

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Subcellular Location

Nucleus.

Protein Families

MYT1 family

Tissue Specificity

Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.

Database Links

HGNC: 7622

OMIM: 600379

KEGG: hsa:4661

STRING: 9606.ENSP00000327465

UniGene: Hs.279562

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

MAPK Erk pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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