Map2 Antibody

Code CSB-PA679670
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA679670(Map2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA679670(Map2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8+10+12%SDS-PAGE, Lysate: 50 μg, Lane: Human lymphoma tissue, Primary antibody: CSB-PA679670(Map2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds
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Product Details

Uniprot No. P20357
Target Names Map2
Alternative Names Map2 antibody; Mtap2 antibody; Microtubule-associated protein 2 antibody; MAP-2 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of Mouse Map2
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
WB 1:200-1:1000
IHC 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Gene References into Functions
  1. MAP2c levels in different brain regions of aging mice were positively correlated with neuropsin expression. PMID: 24965600
  2. Accumulation of intraneuronal beta-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses. PMID: 23372648
  3. results demonstrate the structural and functional determinant underlying the v-KIND-MAP2 interaction that controls dendrite arborization patterns PMID: 21385318
  4. Increased MAP2 expression in malignant melanoma cells significantly inhibits tumor cell growth and neoplasm invasiveness, and induces apoptosis and cell cycle arrest. PMID: 20100193
  5. Data show that inhibition of ZNF238 (RP58) expression in mouse GNPs decreases the expression of the neuronal differentiation markers MAP2 and NeuN and downregulates the expression of the cell cycle arrest protein p27, a regulator of GNP differentiation. PMID: 20103640
  6. Nitric oxide affects the phosphorylation state of microtubule-associated protein 2 in brain. PMID: 11829530
  7. PKA binding to MAP2 and MAP2 phosphorylation is essential for the selective development of contextual memory. PMID: 12763072
  8. Multiple brain regions exhibit potential for endogenous recovery and/or reorganization of MAP2 after injury of moderate traumatic severity. PMID: 14588114
  9. As young adults, S100B transgenic mice exhibit significantly greater MAP-2-immunoreactivity in the hippocampus, however in older adults, less MAP-2 staining is exhibited. PMID: 15306236
  10. JNK1 phosphorylation of MAP2 plays an important role in defining dendritic architecture in the brain. PMID: 16000625
  11. We also propose MAP2-deficient mice as an ideal system for identifying protein phosphatases essential for dendritic functions. PMID: 16257389
  12. MAP2 was increased in old females compared with both young and middle-age females with no significant difference in males, suggesting it may constitute a compensatory response to age-related functional decline in mice. PMID: 16330151
  13. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites PMID: 16901895
  14. v-KIND mediates a signaling pathway that links Ras and MAP2 to control dendrite growth PMID: 17984326
  15. AKAP150 and Mtap2 put TREK channels at the center of a complex protein network that finely tunes channel trafficking, addressing, and regulation. PMID: 18716213

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Subcellular Location Cytoplasm, cytoskeleton, Cell projection, dendrite
Database Links

KEGG: mmu:17756

STRING: 10090.ENSMUSP00000109650

UniGene: Mm.256966

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