NAA15 Antibody

Datasheet

Code	CSB-PA863143LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat brain tissue, Rat kidney tissue, Mouse heart tissue, Mouse liver tissue All lanes: NAA15 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 102, 62 kDa Observed band size: 95 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NAA15 Polyclonal antibody

Uniprot No.

Q9BXJ9

Target Names

NAA15

Alternative Names

5730450D16Rik antibody; 6330400I15 antibody; ASTBDN antibody; GA19 antibody; Gastric cancer antigen Ga19 antibody; MGC29428 antibody; mNAT1 antibody; N alpha acetyltransferase 15, NatA auxiliary subunit antibody; N terminal acetyltransferase antibody; N(alpha) acetyltransferase 15, NatA auxiliary subunit antibody; N-alpha-acetyltransferase 15 antibody; N-terminal acetyltransferase antibody; Naa15 antibody; NAA15_HUMAN antibody; NatA auxiliary subunit antibody; NATH antibody; NMDA receptor regulated 1 antibody; NMDA receptor regulated protein 1 antibody; NMDA receptor-regulated protein 1 antibody; Protein tubedown 1 antibody; Protein tubedown-1 antibody; Tbdn 1 antibody; Tbdn100 antibody; Transcriptional coactivator tubedown 100 antibody; tubedown-1 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat, Mouse

Immunogen

Recombinant Human N-alpha-acetyltransferase 15, NatA auxiliary subunit protein (742-865AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NAA15 Antibody (Product code: CSB-PA863143LA01HU) is Non-conjugated. For NAA15 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA863143LB01HU	NAA15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA863143LC01HU	NAA15 Antibody, FITC conjugated
Biotin	CSB-PA863143LD01HU	NAA15 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Gene References into Functions

individuals with copy-number variant (CNV) deletions involving NAA15 and surrounding genes can present with mild intellectual disability, mild dysmorphic features, motor delays, and decreased growth. PMID: 29656860
In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
Authors highlight NAA15 as a novel candidate ID gene based on the vital role of NAA15 in the generation and differentiation of neurons in neonatal brain. PMID: 28990276
Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
Development of the first N-terminal acetyltransferase (NAT) inhibitors, including inhibitors to the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH). PMID: 23557624
Protein N-terminal acetyltransferases (NATs), including the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH), act as N-terminal propionyltransferases. PMID: 23043182
Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
NATH, a novel gene overexpressed in papillary thyroid carcinomas. PMID: 12140756
description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
Loss of retinal endothelial Tbdn-1 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity. PMID: 16518308
Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
NATH complexes with hARD1 in a ribosomal associated protein-N-acetyltransferase complex. PMID: 15496142

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Subcellular Location

Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Tissue Specificity

Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, u

Database Links

HGNC: 30782

OMIM: 608000

KEGG: hsa:80155

STRING: 9606.ENSP00000296543

UniGene: Hs.745047

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