NAA15 Antibody

Code CSB-PA863143LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Rat brain tissue, Rat kidney tissue, Mouse heart tissue, Mouse liver tissue
    All lanes: NAA15 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 102, 62 kDa
    Observed band size: 95 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NAA15 Polyclonal antibody
Uniprot No.
Target Names
NAA15
Alternative Names
5730450D16Rik antibody; 6330400I15 antibody; ASTBDN antibody; GA19 antibody; Gastric cancer antigen Ga19 antibody; MGC29428 antibody; mNAT1 antibody; N alpha acetyltransferase 15, NatA auxiliary subunit antibody; N terminal acetyltransferase antibody; N(alpha) acetyltransferase 15, NatA auxiliary subunit antibody; N-alpha-acetyltransferase 15 antibody; N-terminal acetyltransferase antibody; Naa15 antibody; NAA15_HUMAN antibody; NatA auxiliary subunit antibody; NATH antibody; NMDA receptor regulated 1 antibody; NMDA receptor regulated protein 1 antibody; NMDA receptor-regulated protein 1 antibody; Protein tubedown 1 antibody; Protein tubedown-1 antibody; Tbdn 1 antibody; Tbdn100 antibody; Transcriptional coactivator tubedown 100 antibody; tubedown-1 antibody
Raised in
Rabbit
Species Reactivity
Human, Rat, Mouse
Immunogen
Recombinant Human N-alpha-acetyltransferase 15, NatA auxiliary subunit protein (742-865AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NAA15 Antibody (Product code: CSB-PA863143LA01HU) is Non-conjugated. For NAA15 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA863143LB01HU NAA15 Antibody, HRP conjugated ELISA
FITC CSB-PA863143LC01HU NAA15 Antibody, FITC conjugated
Biotin CSB-PA863143LD01HU NAA15 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
Gene References into Functions
  1. individuals with copy-number variant (CNV) deletions involving NAA15 and surrounding genes can present with mild intellectual disability, mild dysmorphic features, motor delays, and decreased growth. PMID: 29656860
  2. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
  3. Authors highlight NAA15 as a novel candidate ID gene based on the vital role of NAA15 in the generation and differentiation of neurons in neonatal brain. PMID: 28990276
  4. Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
  5. Development of the first N-terminal acetyltransferase (NAT) inhibitors, including inhibitors to the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH). PMID: 23557624
  6. Protein N-terminal acetyltransferases (NATs), including the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH), act as N-terminal propionyltransferases. PMID: 23043182
  7. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
  8. NATH, a novel gene overexpressed in papillary thyroid carcinomas. PMID: 12140756
  9. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
  10. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
  11. Loss of retinal endothelial Tbdn-1 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity. PMID: 16518308
  12. Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
  13. NATH complexes with hARD1 in a ribosomal associated protein-N-acetyltransferase complex. PMID: 15496142

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Subcellular Location
Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
Tissue Specificity
Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, u
Database Links

HGNC: 30782

OMIM: 608000

KEGG: hsa:80155

STRING: 9606.ENSP00000296543

UniGene: Hs.745047

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