NANOS2 Antibody

Datasheet

Code	CSB-PA015437LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA015437LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA015437LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NANOS2 Polyclonal antibody

Uniprot No.

P60321

Target Names

NANOS2

Alternative Names

NANO2_HUMAN antibody; Nanos homolog 2 antibody; Nanos homolog 2 Drosophila antibody; NANOS2 antibody; NOS-2 antibody; NOS2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nanos homolog 2 protein (1-138AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NANOS2 Antibody (Product code: CSB-PA015437LA01HU) is Non-conjugated. For NANOS2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA015437LB01HU	NANOS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA015437LC01HU	NANOS2 Antibody, FITC conjugated
Biotin	CSB-PA015437LD01HU	NANOS2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.

Gene References into Functions

We conclude that heterogeneous population of the HEK293T cells might be easily shifted towards expression of the pluripotency markers by ectopic expression of the SON factors or by growth in serum depleted media. PMID: 27794480
The increased NO production with increased expression of iNOS and ncNOS may contribute to the pathological and physiological features of UVB-induced erythema and skin inflammation. PMID: 14615895
Data describe for the first time the expression pattern of the NANOS2 gene in human tissues and show that it is testis specific. We found that NANOS2 protein is present in prenatal germ cells and at later stages in spermatogenesis. PMID: 19168545

Subcellular Location

Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region.

Protein Families

Nanos family

Tissue Specificity

Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).

Database Links

HGNC: 23292

OMIM: 608228

KEGG: hsa:339345

STRING: 9606.ENSP00000341021

UniGene: Hs.434218

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Phage Display Service

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Protein Service

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Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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