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NANOS2 Antibody, FITC conjugated

Datasheet
Code CSB-PA015437LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NANOS2 Polyclonal antibody
Uniprot No.
P60321
Target Names
NANOS2
Alternative Names
NANO2_HUMAN antibody; Nanos homolog 2 antibody; Nanos homolog 2 Drosophila antibody; NANOS2 antibody; NOS-2 antibody; NOS2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nanos homolog 2 protein (1-138AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

NANOS2 antibodies

NANOS2 Proteins

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Target Background

Function
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.
Gene References into Functions
  1. We conclude that heterogeneous population of the HEK293T cells might be easily shifted towards expression of the pluripotency markers by ectopic expression of the SON factors or by growth in serum depleted media. PMID: 27794480
  2. The increased NO production with increased expression of iNOS and ncNOS may contribute to the pathological and physiological features of UVB-induced erythema and skin inflammation. PMID: 14615895
  3. Data describe for the first time the expression pattern of the NANOS2 gene in human tissues and show that it is testis specific. We found that NANOS2 protein is present in prenatal germ cells and at later stages in spermatogenesis. PMID: 19168545
Subcellular Location
Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region.
Protein Families
Nanos family
Tissue Specificity
Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
Database Links

HGNC: 23292

OMIM: 608228

KEGG: hsa:339345

STRING: 9606.ENSP00000341021

UniGene: Hs.434218

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