NBR1 Antibody

1. NBR1 is not required for PARK2-dependent mitophagy. PMID: 26512954
2. The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID: 26903539
3. NBR1 positively correlates with adipose inflammation in human obese patients. PMID: 25043814
4. Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID: 24879152
5. The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID: 24769734
6. structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID: 24692539
7. results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID: 23239026
8. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID: 22484440
9. The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID: 21121670
10. Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID: 22728060
11. Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID: 22430266
12. AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID: 21606687
13. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
14. interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID: 11856312
15. NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID: 19398892
16. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

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HGNC: 6746

OMIM: 166945

KEGG: hsa:4077

STRING: 9606.ENSP00000343479

UniGene: Hs.277721