NDUFS3 Antibody

Datasheet

Code	CSB-PA015662ESR1HU
Size	US$166
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Image	Western blot All lanes: NDUFS3 antibody at 1.98μg/ml Lane 1: Mouse brain tissue Lane 2: Mouse skeletal muscle tissue Lane 3: Mouse heart tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31, 15 kDa Observed band size: 31 kDa Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015662ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA015662ESR1HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA015662ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NDUFS3 Polyclonal antibody

Uniprot No.

O75489

Target Names

NDUFS3

Alternative Names

CI 30 antibody; CI 30KD antibody; CI-30kD antibody; Complex I 30KD antibody; Complex I 30kDa subunit antibody; COMPLEX I, MITOCHONDRIAL RESPIRATORY CHAIN, 30-KD SUBUNIT antibody; Complex I-30kD antibody; mitochondrial antibody; NADH coenzyme Q reductase antibody; NADH dehydrogenase (ubiquinone) Fe S protein 3 30kDa antibody; NADH dehydrogenase [ubiquinone] iron sulfur protein 3 mitochondrial antibody; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 antibody; NADH dehydrogenase ubiquinone 30 kDa subunit antibody; NADH-ubiquinone oxidoreductase 30 kDa subunit antibody; NADH-Ubiquinone Oxidoreductase Fe-S Protein 3 antibody; NDUFS3 antibody; NDUS3_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial protein (37-264AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Gene References into Functions

identified a novel Leigh syndrome causing NDUFS3 mutation and expanded the clinical spectrum caused by NDUFS3 mutations in this study. PMID: 30140060
The results suggest that the impaired mitochondrial activity could be due to the broken interaction between DJ-1 and NDUFS3 and that downregulation of DJ-1 in sperm and testes contributes to AS pathogenesis. PMID: 29849492
The NDUFS3 expressed in the temporal cortex in patient with late-onset Alzheimer's disease. PMID: 28242297
High NDUFS3 expression is associated with IgA nephropathy. PMID: 25770168
pH stability of w-t and Leigh syndrome mutant varied at extreme acidic pH. the molten globule like structure of w-t at pH1 was absent in case of the mutant protein. Both the w-t and mutant proteins showed multi-step thermal and Gdn-HCl induced unfolding PMID: 24028823
NDUFS3 is down-regulated in serous ovarian adenocarcinoma PMID: 23446378
Expressions of GRIM-19, NDUFS3, and extracellular matrix elements are correlated with invasive capabilities of breast cancer cell lines. PMID: 23630608
a novel, biomarker potential of a mitochondrial complex I subunit protein, NDUFS3 - as a robust indicator of breast cancer progression and invasiveness as well as of hypoxia/necrosis in clinical specimens of invasive ductal carcinoma, was uncovered. PMID: 21867691
Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains. PMID: 11771736

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Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Protein Families

Complex I 30 kDa subunit family

Database Links

HGNC: 7710

OMIM: 603846

KEGG: hsa:4722

STRING: 9606.ENSP00000263774

UniGene: Hs.502528

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Oxidative Phosphorylation

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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