NFYB Antibody

Code CSB-PA015774ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA015774ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA015774ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) NFYB Polyclonal antibody
Uniprot No. P25208
Target Names NFYB
Alternative Names CAAT box DNA binding protein subunit B antibody; CAAT box DNA-binding protein subunit B antibody; CBF A antibody; CBF B antibody; CCAAT binding transcription factor subunit A antibody; HAP 3 antibody; HAP3 antibody; NF Y protein chain B antibody; NF YB antibody; NF-YB antibody; NFYB antibody; NFYB_HUMAN antibody; Nuclear transcription factor Y beta antibody; Nuclear transcription factor Y subunit B antibody; Nuclear transcription factor Y subunit beta antibody; Transcription factor NF Y B subunit antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Nuclear transcription factor Y subunit beta protein (1-207AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Gene References into Functions
  1. The nuclear transcription factor Y subunit beta (NFYB)-E2F transcription factor 1 (E2F1) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC. PMID: 29203250
  2. NF-YB transcription factor was identified as a novel direct E2F1 target. PMID: 26039627
  3. The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif. PMID: 23595228
  4. Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia. PMID: 22132193
  5. NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L PMID: 21445285
  6. MicroRNA-485-3p regulates drug responsiveness by decreasing nuclear factor-YB expression, which in turn negatively regulates DNA topoisomerase IIalpha. PMID: 21252292
  7. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. PMID: 12401788
  8. CBF/NF-Y proteins regulate the transcription of COL11A1 by directly binding to the ATTGG sequence in the proximal promoter region PMID: 12805369
  9. Co-operative functional interactions between Sp1 & NF-Y are required to direct the activity of the ATP1A3 promoter predominantly in neuronal cells. PMID: 15462673
  10. trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation. PMID: 18275041
  11. CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization PMID: 18480411

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Subcellular Location Nucleus
Protein Families NFYB/HAP3 subunit family
Database Links

HGNC: 7805

OMIM: 189904

KEGG: hsa:4801

STRING: 9606.ENSP00000240055

UniGene: Hs.84928

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