NMT1 Antibody, HRP conjugated

Code CSB-PA015900LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NMT1 Polyclonal antibody
Uniprot No.
Target Names
NMT1
Alternative Names
Alternative, short form NMT S antibody; EC 2.3.1.97 antibody; Glycylpeptide N tetradecanoyltransferase 1 antibody; Glycylpeptide N-tetradecanoyltransferase 1 antibody; Long form, NMT L antibody; Myristoyl CoA:protein N myristoyltransferase 1 antibody; Myristoyl-CoA:protein N-myristoyltransferase 1 antibody; N myristoyltransferase 1 antibody; NMT 1 antibody; NMT antibody; nmt1 antibody; NMT1_HUMAN antibody; Peptide N myristoyltransferase 1 antibody; Peptide N-myristoyltransferase 1 antibody; Type I N myristoyltransferase antibody; Type I N-myristoyltransferase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Glycylpeptide N-tetradecanoyltransferase 1 protein (1-158AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
Gene References into Functions
  1. Genetic and pharmacologic evidence that inhibiting the N-myristoyltransferase NMT1 suppresses cell-cycle progression, proliferation, and malignant growth of prostate cancer cells. PMID: 29038344
  2. These observations point at a previously unrecognized contribution of calnexin to the retention of NMT1 at the ER membrane. PMID: 26603938
  3. findings suggest that both NMT1 and hnRNP A2/B1 take part in the regulation of HIV-1 RNA expression through their mutual opposite effects on the viral RNA expression in HIV-1-producing cells PMID: 26074144
  4. we propose a model of the Nef:NMT complex in which only the myristoyl moiety holds the two proteins together in complex and speculate that perhaps NMT chaperones Nef to the membrane and thereby protects the myristic acid group from the cytosol PMID: 21449607
  5. In this study, we found decreases in the mRNA levels of human NMT isoforms and the NMT activities in the course of HIV-1 infection in the human T-cell line PMID: 12220649
  6. role of HSC70 in the regulation of NMT PMID: 15156568
  7. NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation PMID: 16123142
  8. Elevated N-myristoyltransferase activity is associated with oral squamous cell carcinoma PMID: 17549352
  9. N-myristoyltransferase may have a role in progression of colonic neoplasms PMID: 18021392
  10. Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence. PMID: 18089753
  11. These results strongly suggest that HIV-1 production is specifically associated with hNMT1, particularly hNMT1(L), but not with hNMT2 in vivo, contributing to the understanding of a step in HIV-1 replication. PMID: 18248763

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Subcellular Location
Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Protein Families
NMT family
Tissue Specificity
Heart, gut, kidney, liver and placenta.
Database Links

HGNC: 7857

OMIM: 160993

KEGG: hsa:4836

STRING: 9606.ENSP00000258960

UniGene: Hs.532790

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