NOP10 Antibody, Biotin conjugated

Datasheet

Citations (1)

Code	CSB-PA873610LD01HU
Size	US$166
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NOP10 Polyclonal antibody

Uniprot No.

Q9NPE3

Target Names

NOP10

Alternative Names

DKCB1 antibody; H/ACA ribonucleoprotein complex subunit 3 antibody; homolog of yeast Nop10p antibody; MGC70651 antibody; NOLA3 antibody; NOP10 antibody; NOP10 ribonucleoprotein homolog (yeast) antibody; NOP10_HUMAN antibody; NOP10P antibody; Nucleolar protein 10 antibody; Nucleolar protein family A member 3 antibody; nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) antibody; snoRNP protein NOP10 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human H/ACA ribonucleoprotein complex subunit 3 protein (1-64AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Citations

The pseudouridine synthase dyskerin binds to cytoplasmic H/ACA-box snoRNA retaining transcripts affecting nuclear hormone receptor dependence F Zacchini,bioRxiv,2021

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Applications : Western blotting analysis

Sample type: Human Cell

Review: Western blotting analysis of purified ribosomes from MCF7 cells shows a co-purification of all pseudouridine-RNP complex (DKC1, NHP2, NOP10, GAR1). RPL5 and RPS14 are shown as a positive control for the ribosomal purification, while eIF4G is used as a control for ribosome-interacting factors.

By Anonymous

Target Background

Function

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Gene References into Functions

Indian aplastic anemia patients did not have NOP10 mutations. PMID: 25906515
Effects of dyskeratosis congenita mutations in NOP10 on assembly of H/ACA pre-RNPs PMID: 20008900
NOP10 has a role in the telomerase complex and telomere maintenance, and in autosomal recessive dyskeratosis congenita PMID: 17507419

Involvement in disease

Dyskeratosis congenita, autosomal recessive, 1 (DKCB1)

Subcellular Location

Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).

Protein Families

NOP10 family

Database Links

HGNC: 14378

OMIM: 224230

KEGG: hsa:55505

STRING: 9606.ENSP00000332198

UniGene: Hs.14317

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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